Browsing by Author "Ajao M. S."

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    Morphometric Analysis of Sella Turcica in Nigerian Adult Cadaveric Dry and Wet Skulls
    (Department of Anatomy, Faculty of Basic Medical Sciences, 2025-06) Kareem S. B.,; Onigbolabi O. G.,; Imam A.,; Ibrahim A.,; Olawepo A,; Ajao M. S.
    Background and Aim: The sella turcica is a saddle-shaped area of bone in the middle cerebral fossa. This region's morphologic heterogeneity may be a sign of pathologic conditions before they show up clinically. The study aimed at comparing the dimensions of sella turcica in both dry and cadaveric skulls and determining the variability in its morphology using dry skulls. Methodology: Twenty-six (15 dry and 11 fresh cadaveric) adults males (16) and females (10) skulls identified as Nigerian by the University of Ilorin Teaching Hospital forensic pathologists, were used. The linear dimensions of the sella turcica were measured, and the shapes were traced out and compared. Social Statistical Package for Social Sciences version 20.0 and a glass prism were used to analyze the size of the sella turcica. Results: The linear measurements showed a statistically significant increase in the depth of the sella turcica of the wet skulls when compared to the dry skulls, but no statistically significant difference (p < 0.05) in other parameters. When the measurements were compared in both sexes, linear measurements had no statistically significant difference. The shapes of sella turcica in dry skulls were concave in 80% and irregular in 20%. Conclusion: Dry and wet skulls exhibited a notable difference in depth; the measurements of the sella turcica were comparable between both sexes. Using dry skulls, the shapes of sella turcica were concave in the majority. Its precise dimensions are helpful in the diagnosis, prognosis, and treatment of pituitary-related disorders.
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    Protective Effect of Nigella sativa (black caraway) oil on oral dichlorvos induced hematological, renal and nonspecific immune system toxicity in wistar rats
    (Arak University of Medical Sciences and Iranian Society of Toxicology, 2017) Adana, M. Y.; Ajao M. S.; Sansa A. B.; Imam A.; Ibrahim A.; Alli-Oluwafuyi A.; Kareem S.B.
    Background: Exposure to environmental toxins such as organophosphates poses a great threat to the health of the public. In this work, we investigated the effects of continuous exposure to dichlorvos (DDVP) on kidney function and hematological parameters, and the possible antidote activity of Nigella sativa oil (NSO). Methods: This research was conducted in 2016, at The Animal Holding and Research Laboratory of Faculty Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria. Twenty-four Wistar rats were randomly divided into four groups, six rats each. The four groups received: 1. phosphate buffer solution as controls, 2. DDVP, 3. DDVP+NSO and 4. NSO alone. After 2 wk of treatment, blood samples were collected and hematological profile (RBC, Hb), erythrocyte indices (MCV, MCH, MCHC, and Plt), renal function parameters (albumin, urea, total protein, chloride, sodium, and potassium ions) and nonspecific immune response (WBC) were measured. Results: Rat exposed to DDVP showed red blood cell count, hemoglobin, packed cell volume, albumin, and total protein levels was reduced from control, while white blood cell count and urea significantly increased as compared to controls, the change in K+ level was not significant. NSO maintained optimal levels of red blood cell count, hemoglobin, packed cell volume, albumin, white blood cell count, and urea, indicative of its protective effect against hemo-, immuno- and nephrotoxicity of DDVP. Conclusion: N. sativa (Black Caraway) oil might be a potential antidote in hematotoxicity, immunosuppression and renal dysfunction in organophosphate poisoning, especially dichlorvos. The protective effect of NSO against dichlorvos toxicity can be attributed to its antioxidant capacity.