Browsing by Author "Aina, S. A."

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    Newbouldia Laevis Enhanced Bcl-2 Expression and Germinal Epithelial Proliferation in adolescent Wistar rats
    (2025-04) Adana, M. Y.; Adebayo, A. D.; Aina, S. A.; Nathan, Q. R.; Onigbolabi, O. G.; Ajao, M. S.
    Background: In traditional medicine, numerous plant extracts have been used as infertility treatments to enhance chances of procreation over the years. The use of Newbouldia laevis as an adjuvant has been shown in experimental animal models to have the ability to either stimulate or suppress male reproductive processes at specific dosages. Th study aimed to compare the effects of graded dosages of Newbouldia laevis and zinc on male fertility. Materials and Methods: Thirty-six male divided into six groups of five adolescent rats each. They were treated with normal saline, Zinc, and different doses and and duration , viz: low-dose short-term (LS) and low-dose long-term (LL), and high-dose long-term (HL) the motility and population groups when compared to other groups. Conclusion/Recommendations: Wistar rats, weighing between 55 - 125 g were randomly high-dose short-term (HS) Newbouldia laevis at for a period of 28 days , for of 56 days . The semen , histomorphometric analysis, and Bcl-2 expression, a protein that controls apoptosis, were studied to assess the testicular health in experimental animals. Results: The results demonstrated that high doses of Newbouldia laevis parameters impaired semen parameters, particularly of sperm cells, irrespective of treatment duration. The population of germinal epithelial cells was unchanged . However, t he expression of Bcl-2 The study suggests that was reduced in the high dose (HS and HL) moderate use of period may have beneficial effects on male fertility potential Newbouldia laevis extract for a limited with effects comparable to those of Zinc.