Browsing by Author "Ahmed, Akeem O."

Now showing 1 - 2 of 2
  • Item
    Haematological, Serum Biochemical and Histopathological Changes in Acute and Sub-Chronic Aqueous Extract of Oyster Mushroom in Male Wistar Rats
    (Faculty of Sciences, Rajshahi University, Bangladesh., 2023) Garuba, Taofeeq; Olabanji, Islamiyat T.; Awogboro, Mariam O.; Olahan, Ganiyu S.; Atunwa, Soliu A.; Ahmed, Akeem O.; Aremu, Abdulfatai; Bolaji Mashhod; Adegboye, A. A.; Sabiu, Saheed
    This study aimed at evaluating toxicological implications of aqueous P. ostreatus extract (POE) in male Wistar rats. POE was prepared in 1:10 (pulverized P. ostreatus : distilled water). In acute toxicity test, single oral dose of 2 mL/kg of POE was administered and observed for 28 days. The sub-chronic toxicity study was conducted by daily oral administration of graded doses (0.25, 0.50 and 0.75 mL/kg b.w) of the extract for 28 days. Clinical signs of toxicity, hematological, serum biochemical parameters and histopathological studies were subsequently evaluated. No treatment-related signs of toxicity or mortality in the animals were recorded in both toxicity tests. Rats administered with lowest dose of POE (25 mL/kg) had highest percentage weight gain. POE had no significant difference (P>0.05) on Red Blood Cell, White Blood Cell (WBC) and differential WBC, and serum biochemistry across all the treated groups when compared to the controls. The result of photomicrographs of stomach, spleen, heart, lung, kidney and liver showed a well outlined arrays of normal tissues in both acute and sub-chronic doses connoting that POE had no toxic effect on them. In view of these, POE may be concluded to be non-toxic within the tested doses and period of investigation
  • Item
    MORPHOLOGY, GROWTH VARIABILITY AND CHEMICAL COMPOSITION OF INDIAN AND NIGERIAN ACCESSION OF OCIMUM SPECIES GROWN IN INDIA
    (Chemistry-Biology Department of North University of Baia Mare Romania., 2019) Patel, Nensi; Patel, Nikita; Patel, Swetal; Ingalhalli, Rajashekhar; Garuba, Taofeeq; Ahmed, Akeem O.; Oyeyinka, Samson A.; Krishnamurthy, Ramar
    Demand for medicinal plants is increasing by the day, due to their health benefits. In this study, the morphological attributes, proximate, mineral and phytochemical compositions of Indian accessions of Ocimum sanctum and Ocimum gratissimum as well as that of Ocimum gratissimum (Nigerian accession) grown in India under greenhouse conditions were investigated. Ocimum leaves showed significant variations in their morphometric attributes and these attributes increased with increasing days after planting. The leaves were good sources of fibre and relatively low in protein. O. sanctum showed superior iron content than the other species. Total phenolic and cardiac glycoside contents of the three leaves were very similar but they showed significant variations in their saponins, tannins, flavonoids and alkaloid contents. PCA revealed that Indian accessions of O. sanctum and O. gratissimum are distinctly separated and different from Nigerian accession of O. gratissimum in morphometric data and phytochemical constituents. Nigerian accession had superior phytochemical contents than the Indian accessions and may be further explored for breeding purposes to complement the Indian accessions for enhanced applications in the pharmaceutical industry in India.