Browsing by Author "Agbaje, S.T."

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    Prevalence of enteric Adenovirus among diarrheic children less than five years in Children’s Specialist Hospital, Ilorin, Kwara State, Nigeria
    (Society for Experimental Biology of Nigeria, 2022) Odebisi-Omokanye, M.B.; Udeze, A.O.; Akinfaye, O.D.; Agbaje, S.T.
    Acute infective gastroenteritis is a major global health problem with children under 5 years of age being predominantly susceptible. Adenoviruses, mainly enteric adenoviruses (EAds) type 40 (Ad40) and type 41(Ad41), have been implicated in causing acute and severe diarrhea in young children worldwide. This study was therefore conducted to elucidate the prevalence and epidemiological features of enteric adenovirus in children aged 0-5 years being managed for acute diarrhea in Children’s Specialist Hospital Ilorin, Kwara State, Nigeria where there is little or no information on its prevalence. A total of one hundred and eighty-eight diarrheic stool samples were obtained and screened for the presence of adenoviruses using monoclonal antibody-based Enzyme Immuno Assay (EIA), (Cortez Diagnostics INC., USA). The results were statistically analysed (Chi-Square and P-value) using descriptive Cross Tab Pearson’s Statistical Method. Adenovirus antigen was detected in 23.4% (44/188) of the diarrheic stool samples. Among the infected patients, children < 2 years old were more vulnerable to enteric adenovirus infection, with the peak infection occurring between 7-12 months of age (28.2% prevalence rate). Also, male children had a higher incidence rate of 13.8% while the female had an incident rate of 9.6%. There was a significant association between marital status (p=0.04) and occupation (p=0.02) of the parent or guardian of the children and adenovirus infection. The findings from this study suggest that adenoviruses are important etiologic agents of diarrhoea in children within Ilorin Metropolis, thusthere is an urgent need for proper diagnosis of adenovirus among children with symptoms of diarrhoea.
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    Seroprevalence of serum IgG of HSV-1 coinfected with HIV infected patients who attended Offa Highly Active Antiretroviral Therapy (HAART) clinic
    (Society of Family Physicians of Nigeria, 2017) Odebisi-Omonkanye, M.B.; Udeze, A.; Agbaje, S.T.; Adeyemi, M.F.; Adeyemi, H.A.; Taiwo, A.
    Purpose: To determine the seroprevalence of IgG of HSV-1 coinfected HIV patients who attended Offa General Hospital, Highly Active Antiretroviral Therapy Clinic (HAART). Methods: A cross sectional study used to study the seroprevalence of IgG of HSV-1 coinfected HIV infected patients that attended Offa Highly Active Antiretroviral Therapy Clinic (HAART). Blood samples were taken from 92 HIV infected patients between January and July 2016. The serum of the patients were examined for HSV-1 IgG with a well calibrated and well validated ELISA machine. Results: Out of the 92 patient, 98.91% were tested positive to HSV-1 IgG. The age distribution, marital status, sex, occupation, CD4 counts, ART(Antiretroviral therapy) had no significant effect on the results because only one person tested negative to HSV-1 IgG. Conclusion: HIVinfected patients are very susceptible to HSV-1 IgG infection Recommendation: HIV infected patients should be counseled on the need to comply with antiretroviral drugs and other drugs