Browsing by Author "Afolabi, S.O."
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Item Adoption and Use of Open educational resources (OER) in distance learning centres of two Nigerian universities(Department of Library and Information Science, Faculty of CIS, University of Ilorin Nigeria, 2021) Isah, A.; Adigun, G.O; Abdulkareem, M.Y.; Afolabi, S.O.Item African derived phytocompounds may interfere with SARS-CoV-2 RNA capping machinery via inhibition of 2′-O-ribose methyltransferase: An in-silico perspective(2022) Gyebi, G.A.; Ogunyemi, O.M.; Adefolalu, A.A.; Rodríguez-Martínez, A.; López-Pastor, J.F.; Banegas-Luna, A.J.; Pérez-Sánchez, H.,; Adegunloye, A.P.; Ogunro, O.B.; Afolabi, S.O.Item Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats.(Elsevier Group, Netherlands, 2021) Ojuade, F.I.; Olorundare, O.E.; Akanbi, O.B.; Afolabi, S.O.; Njan, A.A.Background Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotinamide-induced type 2 diabetic rats. Methods Type 2 diabetes mellitus was induced in overnight fasted rats with a single intraperitoneal injection of streptozotocin (60 mg/kg), followed by the administration of nicotinamide (120 mg/kg) after an interval of 15 min. Diabetic rats were orally administered with; 200, 400 and 800 mg/kg of aqueous extract of Parquetina nigrescens (AEPN), metformin (180 mg/kg) and glibenclamide (1 mg/kg) for two weeks. The effect of treatments on fasting blood glucose, serum insulin, leptin, adiponectin, homa-ir, lipid profile, body weight, pancreatic antioxidants parameters, hepatic glycogen content, glucose-6-phosphate activity, α-amylase inhibition, α-glucosidase inhibition, lipase inhibition and histology of the organs were evaluated. Results Data from this study showed that treatment with AEPN produced a significant reduction (p < 0.05) in fasting blood glucose, glucose-6-phosphatase activity, serum lipase, total triglyceride, total cholesterol, low-density lipoproteins, very low-density lipoprotein, atherogenic index, coronary risk index, pancreatic α-amylase, α-glucosidase and lipase activities. Treatment with AEPN also produced a significant (p < 0.05) increase in; glucose tolerance, glycogen content, leptin, adiponectin and pancreatic antioxidants (glutathione, superoxide dismutase, catalase and high-density lipoproteins). The histology of the organ showed regeneration of the pancreatic tissue after treatment with AEPN. Conclusions This study showed that AEPN exhibited antidiabetic and antihyperlipidemic activity in streptozotocin–nicotinamide-induced type 2 diabetic rats.Item Antimalarial phytochemicals as potential inhibitors of SARS-CoV-2 guanine N7-methyltransferase (nsp 14): an integrated computational approach(2022) Gyebi, G.A.; Ogunyemi, O.M.; Adefolalu, A.A.; López-Pastor, J.F.; Banegas-Luna, A.J.; Rodríguez-Martínez, A.; Pérez-Sánchez, H.; Adegunloye, A.P.; Ogunro, O.B.; Afolabi, S.O.Item Antisecretory and Spasmolytic potential of Ethanolic leaf extract of Datura stramonium Linn in Albino Wistar Rat and Guinea pig ileum models(2016) Afolabi, S.O.; Alli-Oluwafuyi, A.M.; Olorundare, O.E.; Olaleye, S.; Adeyemi, O.O.; Odukanmi, O.Item Apoptotic Potential of Iloneoside from Gongronema latifolium Benth against Prostate Cancer Cells Using In Vitro and In Silico Approach(2024) Gyebi, G.A.; Afolabi, S.O.; Ogunyemi, O.M.; Ibrahim, I.M.; Olorundare, O.E.; Adebayo, J.O.; Koketsu, MItem Cholinergic inhibition and antioxidant potential of Gongronema latifolium benth leaf in neurodegeneration: experimental and in silico study(2024) Gyebi, G.A.; Ejoh, J.C.; Ogunyemi, O.M.; Afolabi, S.O.; Ibrahim, I.M.; Anyanwu, G.O.; Koketsu, M.Item Dual targeting of cytokine storm and viral replication in COVID-19 by plant-derived steroidal pregnanes in silico. Computers in Biology and Medicine, 134; 104406(2021) Gyebi, G.A.; Ogunyemi, O.M; Ibrahim, I.M.; Afolabi, S.O.; Adebayo, J.OItem Iloneoside: a cytotoxic ditigloylated pregnane glycoside from the leaves of Gongronema latifolium Benth(2018) Gyebi, G. A.; Adebayo, J. O.; Olorundare, O. E.; Pardede, A.; Ninomiya, M.; Afolabi, S.O.; Koketsu, MItem Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth(2022) Ogunyemi, O.; Gyebi, G.; Afolabi, S.O.; Paul, J.; Nwaneri-Chidozie, V.; Olorundare, O.EItem Prevention of SARS-CoV-2 cell entry: insight from in silico interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2(2022) Gyebi, G.A.; Adegunloye, A.P.; Ibrahim, I.M.; Ogunyemi, O.M.; Afolabi, S.O.; Ogunro, O.B.Item Probing the multitargeting potential of n-hexane fraction of Gongronema latifolium leaves in neurodegeneration via in vitro, GC–MS and in silico studies(2023) Gyebi, G.A.; Ejoh, J.C.; Ogunyemi, O.M.; Ibrahim, A.M.; Ibrahim, I.M.; Afolabi, S.O.; Batiha, G.E.S.