Browsing by Author "Afodun, A. M."

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    ABO/Rhesus blood group systems are not clinical indicators of male baldness
    (College of Medicine, Ambrose Alli University, Edo, Nigeria, 2017-06) Ayinde, T. O.; Ojulari, L. S.; Sanni, M. A.; Afodun, A. M.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Ayinla, M. T.; Abdulazeez, F. I.; Abdulkareem, S.; Abdulraheem, H. A.; Samotu, K.
    Background: Several disease entities have been linked to the ABO/Rh blood group systems.Baldness or alopecia is the partial or complete lack of hair on the head and/or body. Major advances have been achieved in understanding principal elements of the androgen metabolism involved in the pathogenesis of alopecia, but not much preliminary work has been done in its relationship to blood types. Aim: This study is aimed to determine if there is any association between blood types and male baldness. Methods: 400 male subjects (25-60 years)at Sobi Specialist Hospital Alagbado, Ilorin, kwara State, Nigeria were recruited into the study(200 for control and 200 for baldness).Blood sample was collected from each subject for blood grouping estimation, following the completion of a questionnaire containing information about baldness and haematological profile. Result: The distribution of phenotypic frequencies of ABO group in the control samples were 26.0%, 28.0%, 4.0% and 42.0% for groups A, B, AB and O, respectively, while 92.0% of the subjects were Rh (D) positive and 8.0% Rh(d) negative. And for the baldness, they were 26.0%, 26.0%, 4.0% and 44% for A, B, AB, and O respectively; while Rh (D) positive were 94.0% and Rh (d) negative were 6.0%. The overall result is statistically insignificant (P>0.05) using Pearson Chi-square. Conclusion: The result reflects an absolute parallel relationship between baldness and ABO/Rhesus blood group systems. Thus, ordering for blood group assessment during routine hair clinic as part of ancillary investigation should be discouraged, except if other interests arise.
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    Activation of pro-apoptotic cells, reactive astrogliosis and hyperphosphorylation of tau protein in trimethyltin-induced hippocampal injury in rats
    (Association of Anatomical Societies of Africa, 2020) Okesina, A. A.; Ajao, M. S.; Buhari, M. O.; Afodun, A. M.; Okesina, K. B.; Usman, R. Y.; Sulaimon, F. A.,
    Neurodegenerative diseases cause neural cells to lose both the functional and sensory abilities as a result of genetic factors, proteopathies and mitochondrial dysfunction. Neurodegeneration forms the basis of most neurodegenerative disorders for example Alzheimer’s disease, Huntington’s diseases, and Parkinson’s diseases. The mechanism that underlines the process of neurodegeneration is not well understood. Understanding the process and mechanism involved in neurodegeneration might offer a better therapeutic approach to positively manage cases of neurodegenerative diseases. Therefore, this study’s target was to create an animal model to study neurodegeneration. Sixteen adult male Wistar rats were used in the study and divided into two groups. Control (0.2 mL of normal saline (NS)), and trimethyltin-treated (TMT, 8 mg/kg stat dose only). These animals underwent perfusion with 4% paraformaldehyde, brain excision and analysis of p53 antigen, GFAP and Bielshowsky on these tissues. The results showed that animals in the control group showed presence of activated p53 antigen, reactive astrogliosis, neurofibrillary tangles, and amyloid plaques within the cytoplasm of the hippocampal cells. Cornus Ammonis (CA2) and (CA3) showed more of the trimethylrtin injury than CA1 and CA4. This study thus revealed that, intra-peritoneal administration of single dose of 8mg/kg of trimethyltin can offer an attractive disease model to study some neurodegenerative diseases.