Browsing by Author "Adeyemi, Oluyomi Stephen"
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Item Corrigendum to “Interaction between gallotannin and a recombinant form of arginine kinase of Trypanosoma brucei (TbAK): Thermodynamic and spectrofluorimetric evaluation”(ublished by Hindawi Publishing Corporation in Journal of Biophysics, 2014) Adeyemi, Oluyomi Stephen; Sulaiman, Adenike Faoziyat; Iniaghe, Martin OnomeCurrent chemotherapies against trypanosomiasis are beset with diverse challenges, a situation which underscores the numerous research efforts aimed at finding newer and effective treatments. Arginine kinase of trypanosome has been validated as target for drug development against trypanosomiasis. The present study investigated the interaction between a recombinant form of the arginine kinase (rTbAK) of trypanosome and gallotannin. The interaction between gallotannin and recombinant arginine kinase of Trypanosoma brucei caused significant decrease of enzyme activity. Kinetic analysis revealed the interaction to be of noncompetitive inhibition. Further thermodynamic analysis showed that the interaction between gallotannin and the recombinant arginine kinase was nonspontaneous and involved hydrophobic forces. The 𝐾sv values and the FRET analysis suggest that static quenching of fluorescence intensity by gallotannin was static.Data revealed inhibitory interactions between gallotannin and rTbAK of trypanosome. Although themechanism of inhibition is not clear yet, molecular docking studies are ongoing to clearly define the inhibitory interactions between the gallotannin and rTbAK.The knowledge of such binding properties would enrich development of selective inhibitors for the arginine kinase of Trypanosoma brucei.Item CRITICAL DISCUSSION ON THE APPLICATIONS AND IMPLICA-TIONS OF CHEMICALS IN SANITIZERS AND DISINFECTANTS(Leibniz Research Centre for working Environment and Human Factors, 2020-06-15) Atolani, Olubunmi; Baker, Mariam Temitope; Adeyemi, Oluyomi Stephen; Olanrewaju, Ismaeel Ridwan; Hamid, Abdulmumeen A.; Ameen, Oloduowo M.; Oguntoye, Stephen O.; Usman, Lamidi A.