Browsing by Author "Adeyemi, S.B"

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    Bioclimatic Modeling of Current Geographic Distribution and Future Range Shifts of Selected Edible Mushrooms in Nigeria
    (Faculty of Life Sciences, Federal University Dutsin-Ma, Nigeria, 2024-03-31) Tiamiyu, B.B; Lateef ,A.A; Ajadi, I; Adeyemi, S.B; Owolabi, P.O; Sagaya, A; Abdulsalam, M; Abdulkareem, K.A; Mustapha, O.T
    Mushrooms, as part of the fungal kingdom, are essential components in nutrient cycling and carbon retention in terrestrial ecosystems. Monitoring the impact of climate change on fungi in their natural habitat is difficult because most species reside below the soil surface. As a result of a few reported occurrence records in Nigeria, we model the species distribution of two edible mushrooms, namely, Pleurotus ostreatus and Macrolepiota procera, using MaxEnt to predict the potential future range shifts under different climate change scenarios. In this study, we have calculated high model performances based on the Area under Curve (AUC) values generated (0.778-0.873). Using this modeling approach, the two species were predicted to have an expansion of their localized fundamental niches, pointing to the influence of precipitation as an important macroclimatic predictor. Highly suitable habitats for the two species were discovered primarily in Southern Nigeria, with less habitat suitability in the North-central Zone in 2050. The predicted models in this study do not tell missing geographical information, which could be achieved through citizen science for occurrence records and biodiversity conservation. However, they may be used to explore potentialities, such as understanding the possible distribution patterns of the two mushroom species in Nigeria. This can serve as a useful baseline to enhance the utilization and conservation efforts of these macrofungi as a result of climate change, habitat loss, and rapid urbanization.
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    Comparative studies of genotoxicity and anti-plasmodial activities of stem and leaf extracts of Alstonia boonei (De Wild) in malaria-infected mice
    (Parasitology and Public Health Society of Nigeria, 2017-09) Babamale, O.A; Iyiola, O.A; Adeyemi, S.B; Sulaiman, A.F; Abdulkareem, A.O; Anifowoshe, A.T; Awe, O.D; Ajani, D; Ugbomoiko, U.S
    Drug resistance in malaria infection is a serious public health challenge. Thus, scientific search for alternative treatment measures among the local medicinal plants is exigent. We therefore investigated the anti-plasmodial efficacy and genotoxicity of the methanolic leaf and stem extracts of Alstonia plant at varying concentration (200 mg/kg, 400 mg/kg and 600 mg/kg) in mice infected with chloroquine sensitive Plasmodium berghei. The phytochemical screening of the extract revealed that leaf sample contained significantly higher secondary metabolites, except saponins (p<0.05). Anti-plasmodial activities of the two extracts were duration and dose- dependent. Stem bark extract showed higher curative potential with inhibition rate of 56.71% at 400 mg/kg whereas, leaf extract was efficient at 600mg/kg with 52.15% inhibition rate. Stem bark extract at 400 mg/kg improved the enzymatic activities of the mice; it lowered serum ALT (6.88±4.42) and increased liver ALT (41.07±5.56). Similarly, 400 mg/kg leaf extract showed highest AST (70.65±4.00) and ALT (44.65±7.83) activities in the kidney and liver respectively. Analysis of genotoxicity revealed that micronucleus and abnormal (binucleated, notched and blebbed) were prevalent among the experimental mice which increased significantly (p<0.05) at all concentrations except at 600mg/kg leaf extract. Therefore, this present study indicates that both leaf and stem bark extracts of A. boonei possess anti-plasmodial activity and are less genotoxic when compared with standard drug.
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    Molecular Characterization of Potential Crop Pathogens Associated with Weeds as Endophytes in Uniilorin Plantations, Nigeria
    (College of Science for Women/ University of Baghdad, 2022-05-20) Lateef, A.A; Garuba, T; Abdulkareem, K.A; Olayinka, B.U; Olahan, G.S; Adeyemi, S.B; Abdulrahaman, A.A
    Crop diseases are usually caused by inoculum of pathogens which might exist on alternate hosts or weeds as endophytes. These endophytes, cum pathogens, usually confer some beneficial attributes to these weeds or alternate hosts from protection against herbivores, disease resistance, stress tolerance to secondary metabolites production. This study was therefore carried out to isolate potential crop pathogens which exist as endophytes on weed species in the University of Ilorin plantations. Green asymptomatic leaves were collected from 10 weed species across the plantations, and processed for their endophytic fungi isolation. Isolates were purified into pure cultures and used for molecular identification using the internal transcribed spacer (ITS) region of the ribosomal DNA. Phylogenetic analysis of the fungal sequences using MEGA software revealed 9 fungal genera belonging to 13 species, with species in the genera Curvularia, Epicoccumand Daldinia occurring in more than one weed species, while other genera such as Alternaria, Fusarium, Chaetomium, Macrophomina, Arthrinium and Phomopsis occurred in just one weed species each. Daldinia eschscholtzii was isolated in this study as an endophyte from Loudetia arundinacea for the first time. This plant is very abundant in Nigeria and Africa where it is used majorly for thatching and feeding livestocks. This also represents the first endophytic fungi from the genus Loudetia. Potential relationship between the occurrences of these fungi as endophytes and as pathogens are discussed. These discoveries represent the first large-scale molecular identification and several first reports of endophytes from these weed species. These results also represent the first records of some of these fungi in Nigeria.
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    Phylogenetic Position of Nigerian Species of Curcuma longa (Zingiberaceae) in the Current Infrageneric Classification
    (The College of Natural and Applied Sciences, Fountain University, Osogbo, Nigeria, 2024) Tiamiyu, B.B; Lateef, A.A; Sagaya, A; Abdulkareem, K.A; Olayinka, B.U; Ayinla, A; Adeyemi, S.B; Amenu, S.G; Abdulrahaman, A.A; Mustapha, O.T
    Curcuma longa L. (commonly known as Tumeric) is the only species of the genus Curcuma found in Nigeria. It is of great economic importance to Nigeria, Africa, Asia, and other parts of the world, where it is widely used for ornamental and medicinal purposes, and as spices in food and beverages. However, the phylogenetic placement of the turmeric plant (C. longa) in Nigeria is far from being fully resolved, hence the need for this study. The rhizomes of turmeric were collected at the Forestry Research Institute of Nigeria, Ibadan, Oyo state. Genomic DNA was extracted, followed by the amplification of the ITS and psbA-trnH regions. Phylogenetic analysis was conducted using the Maximum likelihood method. The result resolved the phylogenetic position of Nigerian species and supported existing subgenera classification into three clades, all with high bootstrap support for the three clades. The result of this study supports the subgenera classification of the genus and further reveals the phylogenetic position of C. longa.
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    Secondary Metabolites constituents and Antibacterial Screening of Methanolic Leaves Extracts of Senna fistula and Ocimum gratissimum.
    (College of Health Sciences, University of Ilorin, Nigeria, 2019) Ayinla M.T; Adeyemi, S.B; Owoyele, B.V.; Krishnamurthy, R
    The misuse of antibiotics has contributed largely to the development of resistance strains thereby creating the need for an incessant search and development of newer drugs. This study investigated the secondary metabolites constituents and antibacterial activity of methanolic leaves extracts of Senna fistula (SF) and Ocimum gratissimum (OG). The SF and OG leaves extracts were done using methanol, the phytochemical analysis were done as per standard protocol. The antibacterial activity was determined by agar well diffusion method. The results showed that the methanolic leaves extracts of SF and OG contain secondary metabolites like flavonoids, tannins, alkaloids, terpenoids, cardiac gylcosides, saponins, phenolic compounds. The antibacterial screening revealed that both Senna fistula and Ocimum gratissimum exhibited strong inhibitory activity against all the tested organisms. Methanolic leaf extract of SF has a stronger antibacterial activity with zones of inhibition of 19.5mm against E coli and 31.5 mm against Klebsiella than methanolic leaf extract of OG (18 mm against E coli and 28 mm against Klebsiella) in a dose dependent manner. In conclusion, the methanolic leaves extracts of Senna fistula and Ocimum gratissimum exhibited antibacterial activity which is due to the presence of various secondary metabolites; therefore this study supports its use as an antibiotic agent.
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    Toxicological Assessment of Silver Nanoparticles and Colchicine on Biochemical Indices in Albino Wistar Rats
    (Centrepoint Journal (Science Edition), Published by University of Ilorin, 2017-07-13) SULAIMAN, A. Faoziyat; Iyiola, Oluyinka Ajibola; Sulaiman, A. Abdulfattah; Quadri, A.L; Oyegoke, R.A; Adisa, M.J; Adeyemi, S.B; Adebayo, Maimunat Adetutu; Itadare, Oluwasola Beatrice
    Silver nanoparticles (AgNPs) have numerous biomedical uses due to its excellent biocompatibility, antibacterial activity, antiviral, antifungal and anti-inflammatory activity. The present research was carried out with the aim to determine effect of silver nanoparticles (AgNps) and colchicine on albino wistar rats. The silver nanoparticle was administered at the dosages of 1.11, 1.48, 1.85 and 2.22 mg/kg rat body weight to groups B to E respectively. Group A, which serve as the positive control group was administered with distilled water while group F was treated with a reference drug, called colchicine. The rats were sacrificed under slight anaesthesia twenty-four (24) hours after the last treatment and the effect of the silver nanoparticles and the colchicine on different enzymes and substrates in serum and selected organs were studied. Administration of silver nanoparticle has no significant differences (p > 0.05) on the average body weight, weight of organs and organ-body weight ratios of test rats when compared with the positive control rats. Administration of the silver nanoparticles to the test groups causes a significant alteration (p < 0.05) on the activities of alanine transferase, aspartate transferase, alkaline phosphatase and concentrations of total protein, albumin, urea and creatinine compared with the positive control group. The results obtained suggested that the effects of silver nanoparticles on hepatocytes at high doses (1.85mg/kg and 2.22mg/kg) led to the disruption and leakage of its enzymes into the blood stream. High concentrations of alkaline phosphatase (ALP), Alanine transaminase (ALT) and Aspartate transaminase (AST) were found the serum of the rats, indicating liver damage. We therefore recommend that the usage of silver nanoparticles as drug carrier should be at low doses to prevent hepatotoxicity and other related health issues.