Browsing by Author "Adeyemi, A. A."

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    ANTISICKLING ACTIVITY OF THE FRESH AND DRIED ROOTS OF CISSUS POPULNEA GUILL. ET PERR (VITACEAE)
    (Nig. J. Nat. Prod. and Med., 2015) Adebayo, E. M.; Adeyemi, A. A.; Omotade, O. O.; Fasola, F. A.; Ajayi, T. O.; Attah, F. A.; Famojuro, T. I.; Adebisi, L.; Moody, J. O.
    Research into plants with claimed traditional use in the management of sickle cell anaemia constitutes a useful research strategy in the search for new antisickling drugs and templates. The root of Cissus populnea has been used traditionally in the management of sickle cell disease (SCD). Phytochemical screening of the fresh and powdered sample of the root of C. populnea (CP) was done using standard methods followed by in vitro antisickling evaluation of extracts, solvent-partitioned fraction (ethylacetate) and the vacuum liquid chromatographic fractions (VLC) of the fresh and dried roots of C. populnea with sodium metabisulphite induced sickling of HbSS erythrocytes. p-hydroxybenzoic acid and normal saline were used as positive and negative controls respectively. Phytochemical screening revealed the presence of tannins, saponins and cardiac glycosides. The result of this study showed that the extracts and solvent-partitioned fraction (ethylacetate) from the root of CP have antisickling property with a higher activity for the ethylacetate partitioned fraction of the dried roots compared to that of the fresh roots. The VLC fractions exhibited higher activity than the crude extracts; fraction 3 (FR3) had the maximum activity of 96.4% while 88.6% activity was demonstrated for the standard drug (PABA) at an incubation time of 45 min. This study has thus provided scientific evidence for the traditional use of CP in the management of SCD.
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    In-vitro Antihelmintic and Kill Kinetics Activities of Stem Bark Extracts and Chromatographic Fractions of Chrysophyllum albidum (G. Don)
    (Arch. Bas. App. Med., 2015) Salami, A.T.; Jonah, Daniel; Chukwudi, I. M.; Attah, F. A.; Adeyemi, A. A.; Moody, J. O.; Silva, O.D.
    High resistance prevalent to most antihelmintic drugs has led to the search for alternative treatments. Chrysophyllum albidum G. Don a rain forest tree has folkloric anthelmintic claims. The anthelmintic properties of n-hexane, dichloromethane and methanol extracts and the chromatographic fractions of methanol extract were evaluated. Earthworms washed in distilled water (n=7) were placed in 9cm petri dishes of crude extract with six different concentrations (1,5,10,20,40,60mg/mL) and four concentrations (1, 5, 10 and 20mg/mL) of chromatographic fractions A,B and C. In the study two, liverfluke and tapeworms (n = 7) each washed in distilled water were placed in 9 cm petri dishes of crude methanol extracts of C. albidum (60mg/mL) or chromatographic fractions B or C (10mg/mL and 20mg/mL each). This test was conducted in duplicate. Gross motility and mortality studies were carried out as described by earlier method. Albendazole was used as a reference drug. Data is presented as Mean ± SEM, analysis conducted using two way ANOVA. Methanolic extract of C. albidum (MeCaB) showed the highest anti-helmintic activity at 60mg/mL comparable with Albendazole. Chromatographic fractions B and C (at 10 and 20mg/mL each) showed the highest antihelmintic activities with their time of death and paralysis comparable with Albendazole. Histological evaluation of the dead worms revealed that MeCaB and its' chromatographic fractions caused severe damages of epidermal cells. It can be concluded that methanol extract of Chrysophyllum albidum had greater anti-helmintic activity compared with other extracts and might be a good target plant source for antihelmintic drug development.
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    Milk yield and milk composition of West African dwarf does as influenced by body weight and body temperature.
    (Kebbi State University of Science and Technology, Aleiro, Nigeria, 2021) Yusuff, A. T.; Adeyemi, A. A.; Lawal, M. O.; De campos, J. S.; Ajao, B. H.; Aremu, J. O.
    The study was conducted to determine the effect of bodyweight and body temperature on milk yield and milk composition of West Africa Dwarf (WAD) does. A total number of sixteen lactating WAD does of different body weight were selected for the experiment. The bodyweight and body temperature of the does were taken before every milking period which lasted up to 8 weeks. Milk sample from each doe was subjected to milk composition analysis using milk analyzer. The bodyweight of the does and its corresponding milk yield were grouped into four classes (12 -15 kg, 15.1 -18 kg, 18.1-21 kg, 21.1-24 kg) while the body temperature and its corresponding milk yield and properties were portioned into three ranges (low: 36.10 – 37.00 oC; medium: 37.10 – 38.00 oC; high: 38.10 – 39.00 oC). The data obtained were subjected to one-way analysis of variance of completely randomized design. The results revealed that bodyweight significantly (P<0.05) affects milk yield but not milk composition while body temperature range of 38.10-39.00 oC influences higher milk yield (580.60 ml) It is therefore concluded that WAD does has a relatively stable milk composition irrespective of body temperature or bodyweight while the does of higher body weight produce more milk. It is therefore recommended that body temperature and bodyweight should be among the considerable criteria when selecting WAD goats for dairy purpose.