Browsing by Author "Adewuyi, S."

Now showing 1 - 3 of 3
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    Iron(II) ) & Copper(ll) Complexes Bearing 8- quinolinol with amino- acids mixed ligands: Synthesis. Characterization and Antibacterial Investigation
    (King Saud University, Saudi Arabian, 2014-11-30) Amolegbe, S. A.; Adewuyi, S.; Akinremi, A. C.; Adediji, J. F.; Lawal, A.; Atayese, A. O.; Obaleye, J. A.
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    Some non toxic metal-based drugs for selected prevalent tropical pathogenic diseases
    (Springer and US National Library of medicine, National Institute of Health, 2016-11-30) Amolegbe, S. A.; Akinremi, C. A.; Adewuyi, S.; Lawal, A.; Bamigboye, M. O.; Obaleye, J. A.
    Metal coordination of bioorganic compounds from both natural and synthetic products is not only gaining recognition in drug design and medicinal inorganic chemistry research, also they are being considered in the improvement of the bioactivity of drugs. What is done in this paper is a review of recent advances in the study of coordinationdriven drug delivery, i.e., metal-based drugs (MBDs). The role of some late first row transition metal ions namely Fe, Cu and Zn in the biological activities of metallodrugs such as antimalarials and antimicrobials are highlighted. It was revealed that the interaction between these bio-essential transition metal ions and the organic drugs could enhance the diagnostic and therapeutic potentials of such formed drugs. This is because such interactions were proved to have improved the stability, bioavailability and cell delivery functions of the metallodrugs. Emphasizing on the challenge of metal ions toxicity, the researchers concluded on the need for the development of MBDs to combat drug resistant parasites without causing injury to normal cells. This would be of significance in addressing the concern World Health Organisation of ameliorating the increasing mortality rate in developing countries.
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    Spin- crossover 3D architecture of Fe(II) bearing triazole ligand
    (Chemical Society of Nigeria, 2018-01-26) Amolegbe, S, A.; Adewuyi, S.; Akinremi, A. C; Oladoyinbo, F.A.; Lawal, A.; Sobola, A.O.; Obaleye, J. A.; Hayami, S.
    A new assembled iron (II) complex with triazole derivative, [Fe(pbtrz)6](ClO4)2 : (pbtrz = 4, 4’ - (1, 4 - phenylene)bis - 1, 2, 4 - triazole) was synthesized and well characterized. The ligand showed 3D architectures bridging with iron (II) metal through the N-1 and N-2. The investigation of its magnetic properties has revealed a spin-crossover (SCO) between the low-spin (LS) and the high-spin (HS) states (T1/2 = 242 K) without a thermal hysteresis loop. The spin-crossover regime was also followed by Mössbauer spectroscopy. Furthermore, a photo-induced spin transition otherwise known as light-induced excited spin-state trapping (LIESST- effect) was observed when the complex was illuminated at 5 K.