Browsing by Author "Adepoju, A.M."

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    Atypical chronic myeloid leukaemia in an adolescent nigerian: a case report and review of the literature
    (College of Medicine, Ambrose Alli University, 2017) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Adepoju, A.M.
    Abstract: Atypical chronic myeloid leukaemia (aCML) is a rare subtype of CML which is now regarded as a separate clinical entity and classified among the Myeloproliferative/myelodysplasic syndromes. It lacks the Philadelphia chromosome and BCR-ABL fusion gene found in the classical CML. We report a case of aCML which was diagnosed and managed at the Haematology Department of the University of Ilorin Teaching Hospital, Ilorin. Full blood count showed anaemia, leucocytosisand presence of various forms of myeloid cells with dysplastic features. Bone marrow aspiration done also showed myeloid hyperplasia with dysplastic changes in the myeloid cells. There was poor outcome in the patient. This case illustrates the importance of full haematological investigations of suspected CML cases so that the diagnosis of a CML will not be missed or passed for CML as this could influence choice of treatment and prognosis of patients. There is need for improved diagnostic facilities in tertiary health institutions in the country if we must achieve proper diagnosis and characterization of cases of aCML.
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    Comparative Analysis of Baseline and One Year Post HAART Haematological Parameters in HIV Infected Patients in Ilorin, Nigeria
    (Sikkim Manipal University, 2017) Olawumi, H.O.; Babatunde, A.S.; Adepoju, A.M.; Omokanye, K.O.; Jayeola, A.A.; Ogunfemi, M.K.; Oladosu-Olayiwola, O.R.
    Abstract:Haematological abnormalities are common manifestations of HIV infection. The aim of this study was to determine the effect of HAART on haematological parameters of HIV infected patients.This was a longitudinal prospective study conducted at the HAART clinic of University of Ilorin Teaching Hospital, Ilorin. Eighty newly diagnosed HIV positive patients between 21-75 years who were planned to commence HAART (lamivudine, zidovudine and nevirapine) were recruited into this study. Baseline and one year post- HAART full blood count were carried out by Sysmex KX21 according to manufacturer’s instructions.Twenty nine percent of the patients had anaemia, 13% had neutropaenia and 0.02% had thrombocytopaenia at presentation. There was a significant increase in mean hemoglobin concentration of the patients from 10.79±1.89g/dl at baseline to 11.52±1.27g/dl at one year post HAART initiation. (P value=0.003) There was a statistically significant difference in mean baseline haemoglobin concentration of patients in WHO clinical stages 1, 2 and 3(11.67±1.39g/dl, 10.47±2.09g/dl, 10.00±1.86g/dl respectively; P=0.012). HIV patients were more likely to present with anaemia followed by neutropaenia and rarely thrombocytopaenia. Severity of anaemia increased with disease progression. HAART led to improvement in haematological abnormalities with significant increase in haemoglobin concentration. Haemoglobin concentration may therefore be used to monitor response to HAART in HIV infected patients.