Browsing by Author "Adeniyi, A"
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Item Effect of Management on the profile of serum electrolytes, urea and creatinine in children with Nephrotic Syndrome and Acute Glomerulonephritis in Ilorin(College of Health Sciences, University of Ilorin, Ilorin, Nigeria, 2006) Adedoyin, OT; Anigilaje, EA; Ologe, MO; Adeniyi, APrimary nephrotic syndrome (NS) and acute glomerulonephritis (AGN) are known to cause varying degrees of renal insufficiency depending on the severity. Certain drugs and management strategies used in these two disorders also have profound effect on the serum electrolyte and urea profiles. This study determines the effect of management on the profile of serum electrolytes, urea and creatinine in children with NS and AGN. A retrospective analysis of the biochemical profiles of children admitted with a diagnosis of NS and AGN between 1996 and 2004 was carried out. A total of 21 and 16 children with AGN and NS respectively met the study criteria. There was no significant difference in the serum sodium, potassium and urea in both groups during the study except at the 4th week. The prevalence of hypokalemia in both groups of children was low. The serum sodium and potassium were significantly low compared to those with AGN in the 4th week, while the serum urea and creatinine was higher in NS patients in the same period. There was also generally a low prevalence of hypokalemia throughout the study period. While the study may have confirmed the occurrence of electrolyte imbalance following the use of diuretics, it has also shown that the prevalence of such electrolyte imbalance in the first 4 weeks of treatment is rather low and insignificant despite using significant dose of the drug.Item Febrile Convulsion among Hospitalized Children Aged Six Months to Five Years and Its Association With Haemoglobin Electrophoretic Pattern.(College of Health Sciences, Jimma University, Ethiopia, 2015-07) Adeboye, M.A.N.; Ojuawo, A; Adeniyi, A; Ibraheem, RBACKGROUND: Febrile convulsion and sickle cell disease are common in tropical countries and both are associated with significant morbidity and mortality. Worldwide, Nigeria has the highest prevalence of sickle cell disease. However, there is a dearth of knowledge on the haemoglobin electrophoresis in patients with febrile convulsions. METHODS: This was a hospital based, descriptive, cross-sectional study of the relationship between haemoglobin genotype and febrile convulsion at the University of Ilorin Teaching Hospital over a period of 12 months. A self-designed pretested questionnaire was administered on the subjects, and necessary examinations and investigations were conducted. RESULTS: Of a total of 1675 children admitted into the emergency paediatric unit during the study period, children aged 6 months–5 years that presented with febrile convulsions were 167(10%) . Of this, 1,212 were aged 6 months-5 years. Thus, the age specific, hospital-based prevalence was 13.8%. The M:F was 1.1:1. Their Haemoglobin genotype distribution was AA 131(78.4%), AS 23(13.8%), AC 6(3.6%), SS 6(3.6%), and 1(0.6%) SC. The mean age of the sickle cell disease patients was higher at 46.0±13.5 months compared to 29.2±15.4 months in the non-sickle cell disease patients (p=0.005). The mean packed cell volume in subjects with sickle cell anaemia was 8.8±1.5%; the only case of haemoglobin SC had packed cell volume of 20%, while the non-sickle cell disease patients had a normal PCV. Malaria was present in 80.4% of them. CONCLUSION: Febrile convulsion remains a common cause of hospitalisation. It is uncommon in haemoglobin SS where severe anaemia is always an accompanying derangement. The packed cell volume is nearly normal in children with normal haemoglobin genotype.