Browsing by Author "Ademola, Isaiah Olufemi"
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Item Anticoccidial effects of Morinda lucida acetone extracts on broiler chicken naturally infected with Eimeria species(Taylor & Francis, 2014-09) Ola-Fadunsin, Shola David; Ademola, Isaiah OlufemiContext: The development of drug resistance to Eimeria species in poultry is a reality on farms. This necessitates chemotherapeutic control alternatives, and plant secondary metabolities with activity is one of those potential solutions. Objective: This study was designed to evaluate the efficacy of acetone leaf extract of Morinda lucida Benth. (Rubiaceae) against coccidiosis in broiler chickens. Materials and methods: Acute toxicity of the plant was investigated using 30 one-day-old broiler chicks. Anticoccidial activity investigations were carried out in birds drenched with 2.0, 3.0, 4.0, 5.0 and 6.0 g/kg body weight (BW) of acetone extract of M. lucida leaves once a day for five days, with toltrazuril and untreated controls. The activity was evaluated by means of oocyst inhibition in feces, fecal score, weight gain, mortality and hematological parameters. Results: No sign of toxicity was observed during the acute toxicity test. Fecal oocyst counts decreased steadily in all the treatment groups with time. The anticoocidial efficacy of birds treated with 2.0, 3.0, 4.0, 5.0 and 6.0 g/kg BW of the extract was 91.2, 95.2, 98.7, 99 and 99.5%, respectively. The packed cell volumes, red blood cell counts and white blood cell of the treated birds were not significantly different (p40.05) from the untreated control. However, haemoglobin concentration and weight gain of the treated birds were significantly different (p50.05) from the untreated control. Conclusion: This study is the first to demonstrate the anticoccidial effect of M. lucida on Eimeria parasites. Morinda lucida leaves could therefore find application in anticoccidial therapy.Item Direct effects of Moringa oleifera Lam (Moringaceae) acetone leaf extract on broiler chickens naturally infected with Eimeria species(Springer Science +Business Media Dordrecht, 2013-02-11) Ola-Fadunsin, Shola David; Ademola, Isaiah OlufemiAvian coccidiosis is one of the most important diseases of poultry and it is responsible for a large number of all broiler mortalities worldwide. The control of this disease relies mainly on the use of anticoccidial drugs. However, herbal preparations could be an alternative for the treatment against coccidiosis in chickens. The direct effects of Moringa oleifera acetone extracts on broiler chickens naturally infected with mixed Eimeria species was investigated to determine the relative efficacy of the extracts against coccidiosis in birds. The investigations were carried out in seven groups (ten chickens per group). The birds were given various doses (1.0, 2.0, 3.0, 4.0 and 5.0 g/kg body weight) of acetone extract of leaves of M. toltrazuril® (positive control) and untreated (negative control). The extract was evaluated for anticoccidial activity by means of inhibition of oocyst output in faeces, faecal score, weight gain and mortality. Haematological indices were evaluated by standard methods. The group treated with 1.0 g/ kg body weight Moringa oleifera extract produced the least inhibitory effect on oocyst shed in the faeces (96.4 %), while the groups treated with 2.0 g/kg, 3.0 g/kg, 4.0 g/kg and 5.0 g/kg body weight of the extract produced 97.4, 98.7, 99.1 and 99.8 %, respectively. Body weight gains of infected chickens treated with the extract significantly improved (p<0.05), and faecal scores were milder. Packed cell volume, haemoglobin concentration and red blood count of the treated birds were significantly (p<0.05) higher than those of the infected untreated group. Moringa oleifera leaves could find application in the treatment of avian coccidiosis in veterinary practice.Item Prevalence of gastrointestinal parasites of laboratory animals in Ibadan, Nigeria.(Faculty of Veterinary Medicine, University of Ibadan, 2012) Ademola, Isaiah Olufemi; Ola-Fadunsin, Shola David