Browsing by Author "Adegoke, O.A"
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Item Effect of gliclazide on uric acid and c-reactive protein in alloxan-induced diabetic rats.(University of Ilorin, 2012) Ojulari, L.S.,; Biliaminu, S.A.,; Dangana, E.O.,; Abdulazeez, F.I.,; Ayinde, T.O. .; Adegoke, O.ADiabetes mellitus represent one of the greatest threats to modern global health.Item Improved erythrocyte osmotic fragility and packed cell volume following administration of Aloe barbadensis juice extract in rats.(College of Health Sciences, 2012-07) Ojulari, Lekan; Safiriyu, A.A; Ayinla, M.T; Abdulsalam, J.K; Oyabambi, Adewumi O; Adegoke, O.AAloe barbadensis is a popular house plant that has a long history of a multipipose folks remdy. It has been documented to have anti-diabetic, anti-septic and anti-inflammatory effects. The effect of Aloe barbadensis juice extract on erythrocyte osmotic fragility, packed cell volume and haemoglobin concentration in Wistar rats was investigated. Twenty rats were divided into four groups of five rats each. Group A served as control and received distilled water ad libitum, while group B,C and D were the experimental groups and recieved 50mg/kg, 100mg/kg and 150mg/kg body weight of extract respectively, orally for four weeks. The animals were sacrificed and their blood was collected through cardiac puncture. The erythrocyte osmotic fragility packed cell volume and haemoglobin concentration were detrmined. The results showed significant reductions (p<0.05) in the erythrocyte osmotic fragility in the groups that received 100mg/kg and 150mg/kg of the extract when compared to the group and also significant increases (p<0.05) in the packed cell volume of rats that received 50mg/kg and 100mg/kg body weight of the extract. The results suggest dose dependent protective and modulatory effects of aloe barbadensis on the integrity of the erythrocyte membrane and on the packed cell volume respectively.Item Pregnancy and Fetal Outcomes Following Metformin Use in Diabetic Rats(African Scientist, 2017-03-31) Ojulari, L.S; Morakinyo, A.O; Amali, M.O; Adegoke, O.AThe female reproductive system is responsible for pregnancy and supports development of the fetus. Theincidence of diabetes mellitus (DM) is increasing rapidly worldwide (Wild et al., 2000). Metformin is an oral antidiabetic drug and it seems to have properties that could be beneficial in managing reproductive complications of DM. The present study determined the effect of metformin on pregnancy and fetal outcomes in Alloxan-induced diabetic female Sprague-Dawley rats. Eighty (80) pregnant rats were divided into four groups (20 rats per group). Implantation and pregnancy were first ascertained, and fetal outcome was observed and recorded. The measurement of plasma levels of βhCG, estradiol, progesterone, corticosterone and C-reactive peptide (CRP); were carried out on days 7, 14, 19 and at term. Results were analyzed using ANOVA and Newman Keuls post hoc test with statistical significance taken at p<0.05. Results showed a significant (p<0.05) increase in plasma level of progesterone and estradiol with a significant reduction in CRP levels in the treated groups. The number of fetuses and average litter size was also significantly reduced (p<0.05) in the untreated diabetic rats. No physical abnormalities were observed in litters from all the experimental groups. In conclusion, metformin administration during pregnancy confers maternal and fetal protective effects.Item Taxation and corporate investment: a comparative analysis of Nigeria and Ghana(Departments of Accounting & Finance and Business Administration, Fountain University, Osogbo, 2018) Olaniyi, T.A; Adegoke, O.A; Salman, R.TThis study examines the effect of taxation on Corporate investment in Nigeria and Ghana using panel data that were obtained from financial statements of listed 150 and 48 companies respectively from 1999-2016. The results showed that all explanatory variables used in this study explained 68.4% and 87.2% variation in investment in Nigeria and Ghana respectively. The F-statistics of 8.79 with p of 0.0000 indicates that the model is fit to predict the investment level. The study concludes that corporate income tax and interest significantly affect the level of investment in Nigeria with each variable having a p-value<5 % and negative coefficients parameters of -0.4065 and -0.1646 respectively. Meanwhile exchange rate and import rate are insignificant in explaining the level of investment in Nigeria, with p-values>5%. However, in Ghana, corporate income tax, interest and exchange rate significantly affect investment given their p-values are <5%. These variables have negative coefficient parameters of -0.6575, -6652 and 0.3010 respectively while import rate with a positive coefficient of 6.9373, also has a p-value of 0.9437 indicating an insignificant relationship with the level of investment in Ghana. The study recommends that governments should restructure tax rate and it’s administration in both countries by reducing the company income tax rate from 30 percent to a lower percentage and enforcing strong macroeconomic policies including stabilization of exchange rate and regulation of interest rate charged by lending institutions with a view to reduce the adverse effect of tax rate on corporate investment