Browsing by Author "Abubakar Zubair Lawal"

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    Depressive State Assessment of Pregnant Women Attending the Antenatal Clinic of University of Ilorin Teaching Hospital (UITH), Ilorin, Kwara State, Nigeria
    (Anatomical Society of Nigeria, 2025-02-09) Hidaayah Oluwamayowa Jimoh-Abdulghaffaar; Gwadabe Sadiya Musa; Olanrewaju Saheed Jimoh; Sultan Adeola Bello; Maryprecious Nwakaego Onwunali; Ayomide Simidele Adeojo; Opeyemi Janet Gabriel; Gideon Adedotun Bamishe; Miracle Tosin Alabi; Joshua Adeyinka Afolayan; Maimunat Kewukunmi Abubakr; Boluwatito Emmanuel Okunnu; Aaliyah Oiza Isah; Abubakar Zubair Lawal; Rafiat Oluwatosin Lawal; Maryam Tayo Ayinla; Lekan Sheriff Ojulari
    Antenatal depression, with a global prevalence of between 15 and 65%, is a clinical condition characterised by persistent sadness, anxiety, and hopelessness during pregnancy. It is a strong predictor of postpartum depression, and it negatively impacts pregnancy outcomes, maternal-child bonding, and child development. Untreated antenatal depression could lead to an increased risk of obstetric complications, inadequate prenatal care, poor maternal nutrition, substance abuse, and in severe cases, maternal suicide. Despite being a significant global public health concern, antenatal depression is often overlooked in developing countries like Nigeria, both in terms of research and treatment. Consequently, only a few studies are focusing on antenatal depression, resulting in a poor understanding of the prevalence of depressive symptoms during pregnancy and their associated risk factors. This study aims to fill the gap in knowledge regarding antenatal depression in the Ilorin population. A cross-sectional study was conducted among over 200 pregnant women attending the antenatal clinic at the University of Ilorin Teaching Hospital, where participants were administered a battery of questionnaires (ANRQ, PHQ-9, and QIDSS-163) after obtaining informed consent. The results were analysed using. The results showed that the level of education (ANRQ, QIDSS 16), number of live births (QIDSS-16), age, and number of children (PHQ-9) have a positive impact on the risk and severity of antenatal depression in pregnant women attending the antenatal clinic at UITH. Age, level of education, number of live births, and number of children are strong predictors of the risk and severity of antenatal depression.
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    Effects of salbutamol administration on the morphology and cytoarchitecture of the cerebellum and hippocampus of adult wistar rats
    (Health & Research Journal, 2025-03) AbdulGafar Niyi Popoola; Munirudeen Ibrahim,; Ruqayyah Yetunde Ibiyeye; Ayodeji Amos Faniyi; Musbau Olusesan Balogun; Akeem Olayinka Busari; Wasiu Olanrewaju Garba; Kolawole Ayobami Ogunwale; Abubakar Zubair Lawal; Ibrahim Eleha Suleiman; Godwin Olawoyin Adunmo; Abdulrazak Nuhu
    Abstract Background: Salbutamol is the most preferred and widely used drug for treating bronchial asthma and bronchospasm. Its abuse has however been reported amongst users. Most of the side effects reports on salbutamol are clinical based such as headache, tremor, weakness etc. This study, therefore, investigated the sub-acute effect of oral salbutamol on the general morphology of the cerebellum and hippocampus of adult Wistar rats. Method and Material: Twenty adult Male Wistar rats (125 – 224g) were divided into four groups of five rats each. The control (distilled water); the 20mg/kg salbutamol, the 30mg/kg salbutamol, and the 40mg/kg salbutamol groups. Drugs were administered orally for 21 days. The body weight of each animal was monitored throughout the experiment. On day 22, animals were euthanized, brains excised, fixed in 10% buffered formal-saline, cerebelli and hippocampi were identified and processed with Haematoxylin and Eosin staining tech niques. Data were analysed by ANOVA at p≤0.05 level of significance using SPSS and results presented as mean ± SEM Results: Results showed that the animals that received 30mg/kg and 40mg/kg salbutamol had significant weight loss. The cerebellum of the 40mg/kg group showed eroded granule cell layer. Hippocampus also revealed pyknotic cells in the pyramidal cell layers at 30mg/kg and 40mg/kg. Conclusions: This study showed that salbutamol at relatively higher doses caused significant weight loss; degeneration of cerebellum granule cells, which might affect motor coordination; and pyknosis of hippocampal pyramidal cells which may affect learning and memory. Keywords: Salbutamol, weight loss, brain, degeneration.