Browsing by Author "Abubakar F.A, Oloyede H.O.B and Bamidele B.E"

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    Living and Making Sustainable Choice That Nourish Our Body
    (Department of Biochemistry, University of Ilorin, 2024-04-25) Abubakar F.A, Oloyede H.O.B and Bamidele B.E
    Augmentin, a commonly prescribed antibiotic, poses a risk of liver toxicity, highlighting a significant health concern. This study aimed to explore the potential hepatoprotective effects of cucumber (Cucumis sativus) fruit homogenate against Augmentin-induced liver toxicity in Wistar rats. Thirty-six rats were randomly assigned to six groups: Control, Augmentin-induced (receiving distilled water), silymarin treated + Augmentin-induced, low dose of C. sativus homogenate treated + Augmentin-induced, high dose of C. sativus homogenate treated + Augmentin-induced and Non-induced (receiving C. sativus homogenate). Evaluation encompassed phytochemical analysis of the homogenate, liver function parameters, and histological changes. Results revealed the presence of alkaloids, steroids, glycosides, terpenoids, and saponins in the homogenate. Augmentin administration induced hepatic injury, evidenced by elevated serum liver enzymes and altered histology. However, supplementation with C. sativus fruit homogenate mitigated these effects, leading to decreased liver enzyme levels and improved histological architecture. These findings suggest the potential hepatoprotective properties of C. sativus fruit homogenate against Augmentin-induced liver toxicity, possibly attributed to its phytochemical constituents. Further investigations are needed to delineate the underlying mechanisms and clinical implications of these observed effects. Keywords: Cucumis sativus, fruit homogenate, Augmentin-induced, hepatoprotective, Liver toxicity