Browsing by Author "Abubakar, F.A."

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    Antibacterial Activities of Methanol and Ethanol Extracts of Moringa oleifera (Lam) Leaves
    (Jewel Journal of Scientific Research (JJSR) ): Federal University of Kashere-Nigeria, 2024-12-28) Akanbi-Gada, M. A.; Amubieya O. F.; Abubakar, F.A.; Ajiboye, A. T.; Olorukooba, H. O.; Jimoh, F. A.; Olabamiji, S. T,; Yahaya, Z. O.; Adenekan, A
    Moringa oleifera is known for its therapeutic potential, particularly in treating bacterial infections. This study aimed to determine the Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentration (MBC) of Moringa oleifera extracts (ethanol and methanol) on two bacterial strains: Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive). The extracts were tested at concentrations of 200, 150, 100, 50, and 25 mg/ml. Phytochemical analysis was also conducted. Results showed that Moringa extracts exhibited significant antibacterial activity, with the methanol extract showing an MIC and MBC of 200 mg/ml, and the ethanol extract showing an MIC and MBC of 150 mg/ml. The zones of inhibition were 19 mm (E. coli) and 18 mm (S. aureus) for methanol extract, and 18 mm (E. coli) and 17 mm (S. aureus) for ethanol extract. These results were similar to those of Ciprofloxacin (a standard antibiotic), indicating that Moringa extracts have strong antimicrobial properties. The study suggests that Moringa oleifera could be used as an alternative or adjunct to conventional antibiotics. Future studies should explore the synergistic effects of combining Moringa extracts with existing antibiotics to enhance their effectiveness and combat antibiotic resistance. Keywords: Antibacterial activity; drug-resistance; Escherichia coli; Staphylococcus aureus; phytochemicals.
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    Effects of selected aqueous plant extracts on heamatological parameters of Plasmodium berghei infected mice.
    (Faculty of Physical Sciences and Faculty of Life Sciences, University of Ilorin, Nigeria., 2016) Abubakar, F.A.; Adetutu, A.; Olorunnisola, O.S; Soji-Omoniwa, O; Abdulazeez, A.T; Aborisade, A.B
    Cymbopogon citrates leaves, Khaya senagalesis stem bark, Parquetina nigrescens leaves, Psidium guajava leaves, Terminalia glaucescens stem bark and Zingiber officinale rhizome are used traditionally to treat malaria. This study evaluate the effects of the aqueous extracts of C. citrates leaves, K. senagalesis stem bark, P. nigrescens leaves, P.guajava, T. glaucescens stem bark and Z. officinale rhizome respectively on the heamatological status of NK 65 Plasmodium berghei (chloroquine sensitive parasite) infected mice. Fourty five (45) albino mice with average weight 25.5 ± 1.45g were randomly grouped into nine (9). Mice in group A serve as control not infected. Groups B, C, D, E, F, G, H and I were inoculated intraperitoneally with P. berghei. Groups C, D, E, F, G, H and I were treated with 5 mg/kg body weight of chloroquine, 200mg/kg body weight of C. citrates, K. senagalesis, P. nigrescens, P. guajava, T. glaucescens and Z. officinale aqueous extracts respectively. On day 5, red blood cell count (RBC), white blood cell count (WBC), packed cell volume, haemoglobin count (Hb), lymphocyte and neutrophil counts were assessed. There were significant (p<0.05) increase in the Hb count, RBC and PCV levels of the extract treated P. berghei infected mice in each group when compared with the untreated P. berghei infected mice. In the extracts treated infected mice, lymphocyte count was significantly (p<0.05) increased with concomitant decrease in neutrophil count. Our Findings show that all the extracts used has anti-anaemic properties and anti-inflammatory potential with extracts of P. nigrescens, P. guajava, T. glaucescens and Z. officinale demonstrating higher potential.