Browsing by Author "Abdulrahim HA"

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    ABO/rhesus blood group systems are not clinical indicators of male baldness
    (Annals of Medical Research,, 2017-12-06) Ayinde TO Sanni; Ojulari LS; Afodun AM; Jimoh-Abdulghaffaar HO; Ayinla MT; Abdulazeez FI; Abdulkareem S; Abdulrahim HA; Samotu K
    Background: Several disease entities have been linked to the ABO/Rh blood group systems.Baldness or alopecia is the partial or complete lack of hair on the head and/or body. Major advances have been achieved in understanding principal elements of the androgen metabolism involved in the pathogenesis of alopecia, but not much preliminary work has been done in its relationship to blood types. Aim: This study is aimed to determine if there is any association between blood types and male baldness. Methods: 400 male subjects (25-60 years)at Sobi Specialist Hospital Alagbado, Ilorin, kwara State, Nigeria were recruited into the study(200 for control and 200 for baldness).Blood sample was collected from each subject for blood grouping estimation, following the completion of a questionnaire containing information about baldness and haematological profile. Result: The distribution of phenotypic frequencies of ABO group in the control samples were 26.0%, 28.0%, 4.0% and 42.0% for groups A, B, AB and O, respectively, while 92.0% of the subjects were Rh (D) positive and 8.0% Rh(d) negative. And for the baldness, they were 26.0%, 26.0%, 4.0% and 44% for A, B, AB, and O respectively; while Rh (D) positive were 94.0% and Rh (d) negative were 6.0%. The overall result is statistically insignificant (P>0.05) using Pearson Chi-square. Conclusion: The result reflects an absolute parallel relationship between baldness and ABO/Rhesus blood group systems. Thus, ordering for blood group assessment during routine hair clinic as part of ancillary investigation should be discouraged, except if other interests arise.
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    An assessment on concentrations of No2, So2, Co and their allied health risks alongside Ilorin-Osogbo expressway, Nigeria
    (International Journal of Advanced Biochemistry Research, 2019-06-22) Abdul Raheem AMO; Owolabi AA; Abdulrahim HA
    This research evaluated in-vehicle and ambient air samples for three pollutants; NO2, SO2, CO and deduced the air quality index, emission factors and health risk assessments from the pollutants concentrations. The concentrations of these pollutants were measured in-vehicle using two modes of transportation with open-window scenario while ambient measurements covered three hours of the day at six sampling points covering two states along the highway. NO2, SO2 and CO concentrations were measured with Altair-5X MGD. Vehicular volume was conducted per 45 minutes and self-administered forms were used to draw health data on the samples. The values of the in-vehicle exposure in μgm-3 ranges from 90–1270 NO2; 124-810 SO2 and 3262-23800 CO. The highest average in-vehicle exposure appeared in cars with the following μgm-3 average NO2, 426±109; SO2 571±61 and CO 10433±1650. The Ambient air pollutants results showed that the mean concentrations of NO2 and SO2 exceeded the 1-hour averaging time-limit of 40 μgm-3 set by FEPA but within the 1-hour averaging time-limit set by EPA while the mean concentration of CO falls within minimal limit stipulated by WHO. Air Quality Index was deduced with rating for NO2 and SO2 which ranged from good “A” through unhealthy for sensitive group “UHFS’ to hazardous “F” and rating for CO, F across the sampling points. The study established strong evidence that traffic volume affects the quality of air in the atmosphere at all sampling points. Results from questionnaire indicated some key health risks related with contact to pollutants by commuters and other road users.
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    Knowledge of Oocyte Donation procedure and Health Consequences: a Cross-Sectional Survey of Female Undergraduates in North-Central Nigeria
    (West J Med & Biomed Sci, 2022-05-15) Ameen HA; Olaitan OL; Arimiyau, S; Musa OA; Ibraheem RM; Abdulrahim HA; Aderibigbe SA
    Egg donation is a form of assisted reproductive technology used to help women with infertility. Though, egg donation might attract some material benefit, potential egg donors often do not have knowledge of the associated health risks. This study investigated knowledge of female undergraduates in Kwara State, north central Nigeria, about oocyte donation to infertile couples. It was a descriptive cross sectional study carried out in 2018 involving 559 female undergraduates recruited through a multi-stage sampling technique. An adapted questionnaire validated and tested for reliability was used for data collection. Data were analysed using IBM SPSS version 25 software. Descriptive statistics of frequency count and percentages were used to answer research questions and Chi-square employed to test the hypotheses at <0.05 level of significance. Majority of the respondents were 15-20 years old (66.3%, 371) unmarried (96.8%, 541), Muslims (60.5%, 338), Yoruba (82.8%, 463), first year students (54.4%, 304). Most of the respondents had poor knowledge on oocyte donation (60.3%, 337); poor knowledge of oocyte donation procedure (69.9%, 391) and poor knowledge of the health risks associated with oocyte donation (65.5%, 366). The study revealed that female undergraduates in the study area have poor knowledge of oocyte donation, its procedure and the attendant health consequences. Universities in the study area should include oocyte donation as a topic in General Studies (GNS) in order to equip students with adequate information on potential benefits and drawbacks of oocyte donation.
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    Sub-chronic Use of Levonorgestrel Alters Tissue Lipid Profile, Liver Function and Selected Tissue Cytoarchitecture in Female Wistar Rats
    (Journal of Biomedical and Applied Sciences, 2022) Abdulrahim HA; Fatoki JO; Oyewo EB; Nafiu AB; Omeiza NA; Adekunle AS
    ABSTRACT Background and Objectives: Oral levonorgestrel is a post coitus contraceptive used to prevent unintended pregnancies. The uncontrolled availability of levonorgestrel over-the-counter for sexually active youth, as well as the increasing potential consequences of side effects with frequent use, necessitates research into the effects of repeated levonorgestrel use on selected tissues' cytoarchitectures and biomarkers in female Wistar rats. Methods: Twenty rats (140 ± 20 g) were randomized into four groups: control received 0.2 mL/kg normal saline while others were exposed to oral levonorgestrel at 0.002 mg/kg, 0.004 mg/kg and 0.008 mg/kg, 3 times weekly at 48-hour interval for six weeks. Results: Levonorgestrel increased hepatic total cholesterol, phospholipids and malondialdehyde; renal and cardiac total cholesterol were also found to be elevated in high dose (0.008 mg/kg) levonorgestrel treated rats. Regardless of administered dose, levonorgestrel has a varying effect on tissue triglycerides and GSH and increases serum AST and ALT.. Furthermore, levonorgestrel significantly altered the histoarchitecture of selected tissues in a dose-dependent manner, indicating hepatic karyorrhexis, renal congestion, loss of cortical glomeruli in the kidney, cardiac hypertrophy, endometrial epithelial hypoplasia, disruption of glycoprotein zona pellucida, and uterine glandular atrophy. Conclusion: These findings suggest that levonorgestrel is toxic at non-pharmacological doses by altering tissue lipid profiles and inducing cellular injuries through oxidative and non-oxidative mechanisms. Keywords: Levonorgestrel; Lipid Profile; Liver Function; Cellular Injuries; Oral Contraceptives.