Browsing by Author "Abdulrahim Amin Halimat"

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    Carbamazepine evoked reproductive toxicity in male Wistar rats: protective properties of Moringa oleifera leaves methanolic extract
    (Accelerating the world's research., 2020) Ganiu Jimoh Akorede; Mikail Garba Hudu; Suleiman Folorunsho Ambali; Mohammed M. Suleiman; Kolawole Yusuf Suleiman; Abdulrahim Amin Halimat; Lukman Oladimeji Raji; Isiaku AbdulMajeed
    Carbamazepine is an effective chemotherapeutic agent used to manage individual with epilepsy and trigeminal neuralgia. Chronic use of carbamazepine has been incriminated to cause reproductive disorders. The present study investigates the protec- tive property of Moringa oleifera leaves methanolic extract on chronic carbamazepine-evoked reproductive toxicity in male Wistar rats. Forty male Wistar rats (150–260 g) were randomly separated into four groups with 10 rats, given distilled water (2 ml/kg), M. oleifera (200 mg/kg), carbamazepine (20 mg/kg) and M. oleifera accompanied with carbamazepine, after 30 min. The treatments were administered once in a day for 15 weeks via gavage. The pituitary and testis were evaluated for parameters measuring oxidative challenge, sperm characteristics and histological changes. Sex hormone concentrations were also evaluated from sera samples. The result of the phytochemical analysis shows that M. oleifera leaves extract contain total phenolics (7.8%) and flavonoids (22.23%), which are considered higher in the plant. The results also revealed that exposure to M. oleifera leaves mitigates the disruption in oxidative stress parameters, sex hormone concentration, sperm characteristics and histological chang- es. This study revealed that chronic carbamazepine administration evokes oxidative stress, partly involved in the alterations of concentration of sex hormones, sperm characteristics and histoarchitecture of pituitary gland and testes. Treatment with leaf extract of M. oleifera protects against the adverse reproductive consequences of long-term exposure to CBZ, due to its antioxidant property.
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    Chemical and biological evaluations of potent antiseptic cosmetic products obtained from Momordica charantia seed oil
    (Sustainable Chemistry and Pharmacy, 2018-09) Marili Funmilayo Zubaira; Olubunmi Atolanib; Sulyman Olalekan Ibrahima; Olubunmi Stephen Oguntoyeb; Abdulrahim Amin Halimat; Rukayat Abiodun Oyegoked; Gabriel Ademola Olatunjia
    The Principles of Green Chemistry was employed for the preparation of organic antiseptic soaps with improved skin sensitivity, reduced skin toxicity and improved biodegradability. Non-conventional and lesser known tropical seeds of Momordica charantia were used as the source of oil for the saponification processes. The fatty acid methyl esters of the oil were prepared via transesterification and subjected to GC–MS analysis to obtain the fatty acid composition of the oil and saponified products were subjected to various physicochemical and antimicrobial evaluations. The results indicated that stearic acid (18:0) and eleostearic acid (18:3) were the most abundant fatty acids making up 37.60% and 39.16%, respectively. Palmitic acid (16:0) 12.36%, oleic acid (18:1) 8.71%, linoleic acid (18:2) 0.67% and gamolenic acid (18:3) 1.50% were present in smaller amount in the oil. The oil is a viable source of polyunsaturated fatty acid which is required as essential fatty acids in the human body. The prepared soaps containing only natural additives (such as honey and shear butter) and components showed appreciable degree of hardness comparable to commercial Dudu Osun and the synthetic Lux soaps used as standards. This work demonstrates the probability of the preparation of green antiseptic soaps from the underutilized tropical seed of M. charantia. The seed oil and the allied products obviously have great potential for further advancement, development, research and applications in health and cosmetics sectors. The adopted approach could also assist maintaining a safe and healthy biotic and abiotic environment.
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    Melatonin prevents and ameliorates lead-induced gonadotoxicity through antioxidative and hormonal mechanisms
    (Taxicology And Industrial Health, 2018-04-03) Luqman Aribidesi Olayaki; Isiaka Abdullateef Alagbonsi; Abdulrahim Amin Halimat; Wale Johnson Adeyemi; Muftiat Bakare; Noah Omeiza
    We investigated the effects of melatonin on sperm parameters and some biochemical markers in lead- exposed male Wistar rats. Lead (50 mg/kg bw/day) and/or melatonin (4 mg/kg or 10 mg/kg bw/day) was administered for 4 weeks, while 2-week lead exposure was preceded by or followed by 2-week treatment with both doses of melatonin in other groups. Lead reduced glutathione, catalase, adjusted testes weight, semen parameters but did not change malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase, and total antioxidant capacity. Though independent of prolactin, lead-induced gonadotoxicity was both centrally and peripherally mediated, as it reduced gonadotropin-releasing hormone and testos- terone levels, while gonadotropin levels did not change significantly probably due to negative feedback by elevated estradiol. However, pre-, simultaneous, or posttreatment of lead-exposed rats with melatonin reduced MDA, SOD, and estradiol but dose-dependently increased other parameters. Conclusively, lead causes male gonadotoxicity through oxidative stress and endocrine mechanisms, and these could be dose- dependently prevented and ameliorated by melatonin.