Browsing by Author "Abdulmajeed, Wahab Imam"

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    Ameliorative effects of taurine and caffeine on spatial memory deficit associated with neuropathic pain in sciatic nerve ligated rats
    (Nigerian Journal of Neuroscience, 2015) Abdulmajeed, Wahab Imam; Owoyele, Victor Bamidele
    Despite several clinical studies which showed that majority of chronic pain sufferers have impaired spatial memory, yet, this remains an area of unmet therapeutic need. In this study, we tested whether effect of concurrent administration of taurine and caffeine could restore the spatial memory impairment induced by neuropathic pain. Rats were rendered neuropathic by unilateral sciatic nerve ligation and treated with taurine and caffeine (taurine (200 mg/kg b.w., i.p) + caffeine (7.5 mg/kg b.w., i.p.) and taurine (200 mg/kg b.w., i.p.) + caffeine (15 mg/kg b.w., i.p.). After 2 weeks of administration, the spatial memory was assessed using Y-maze paradigm. The numbers of entries and percentage alternations over a ten minute period was scored for each animal as a measure of spatial memory. Thereafter the animals were sacrificed and blood samples were collected for the estimation of serum C-reactive protein (CRP), a pro-inflammatory marker. Administration of taurine and caffeine ameliorated spatial memory impairment induced by neuropathic pain as percentage alternation increased significantly (P< 0.05) decrease in the serum CRP level in the groups that were treated with taurine alone as well as taurine and caffeine compared to the ligated control group. It can be concluded that administration of taurine and caffeine ameliorated the spatial memory impairment induced by neuropathic pain.
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    Hippocampal-dependent spatial memory and histoarchitectural integrities of the ca regions of wistar rats following administration of rauwolfia vomitoria and chlorpromazine
    (Neuroscience Society of Nigeria, 2015) Ajao, Moyosore Saliu; Imam, Aminu; Ajibola, Musa Iyiola; Abdulmumin, Ibrahim; Amin, Abdulbasit; Adana, Misturah Yetunde; Olawepo, Ayokunle; Abdulmajeed, Wahab Imam
    Psychotic patients demonstrate poor spatial memory, ascribed to impaired hippocampal functions, and bodies of evidences have attributed cognitive impairments to the poor functional outcomes in psychosis management. The efficacy of chlorpromazine and Rauwolfia vomitoria on spatial memory performance and differential histoarchitecture of the hippocampi of adult Wistar rats was examined in this study. Twenty five adult male Wistar rats weighing between 200 - 230 g were randomly grouped to five (Normal, low and high dose chlorpromazine and low and high dose R. vomitoria) of five animals each. 2 ml of normal saline was given to Control animals daily, 5mg/kg of chlorpromazine was given as low dose, 10 mg/kg of chlorpromazine was given as moderate dose, 150 mg/kg of R. vomitoria was given as low dose and 300 mg/kg of R. vomitoria was given as high dose orally. All the medications were given daily for 21 days. A Y-maze apparatus was used to assess the spatial memory performance in the rats at days 14 and 21 of the experiment. All the animals were euthanized using 20 mg/kg of intramuscular ketamine, cardially perfused with 4% paraformaldehyde, the brains and the hippocampus removed for histological analysis. Results from this study show that Rauwolfia at 150 and 300 mg/kg improved the correct decision (right triplet alternation) and reduced wrong decision (wrong triplet alternation) in the treated rats at days 14 and 21 respectively with an unaltered hippocampal histoarchitecture. While chlorpromazine at 5 and 10 mg/kg induced an increased wrong decision (wrong triplet alternation) and reduced correct decision (right triplet alternation) across treatment periods and caused an apparent distortion in the hippocampus. In conclusion, R. vomitoria could be a better alternative agent with more therapeutic potential in the treatment of psychosis and could possibly remediate cognitive impairments in psychosis.