Browsing by Author "Abdulbaqi R."

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    Possible Moringa Oleifers amelioration of atrial fibrillation induced by exposure to petrol vapour in wistar rats
    (Science Association of Nigeria, 2017) Azeez O. M.; Basiru A; Abdulbaqi R.; Olaifa, F. H.; Adah A. S.; Anigbogu, C.N.
    The present study was carried out to investigate the actions of Moringa oleifera aqeous extract in ameliorating the effect of petrol vapour on atrial functions of Winstar rats to that of standard anti hypertensive drugs (captopril and candesartan cilexetil). Twenty five adult male Winstar rats were divided into five groups with five rats in each group. Animals in group 1 (control) were not exposed to petrol fume. Group 2 was exposed to petrol vapour only. Groups 3, 4,and 5 were pretreated with aqueous extract of Moringa oleifera (40mg/kg), captopril (25 mg/kg) and candesartan cilexetil (16mg/kg) respectively before exposure to petrol vapour for10 minutes daily for eight weeks. Exposure to petrol vapour was generated by using human compressor nebulizer adapted for rats and connected to fume chamber where the rats were kept. The pretreatment were administered by gavage using the oral cannula. At the end of the experimental period, rats were anesthetized with 1% chloralose and 25% urethane intraperitoneally; the electrocardiography was done using EDAN 10. The study showed that exposure to petrol vapour resulted in atrial fibrillation and this was ameliorated by ageous Moringa oleifera extract. The result obtained was comparable to that of candesartan. The study concluded that the since the action of Moringa oleifera resembled that of candesartan, Moriga oleifera is suggested to be have an Angiotensin II receptor blocker effects