Browsing by Author "Abdulazeez Iyabode Fatima"

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    IMPACT OF KNOWLEDGE AND PRACTICE OF LIFESTYLE/DIETARY MODIFICATION ON QUALITY OF LIFE OF HYPERTENSIVE PATIENTS: A RANDOMISED CONTROLLED STUDY
    (Universiti Sains Malaysia (USM), 2025-11-28) Jamiu Muslim Olakunle; Abdulazeez Iyabode Fatima; Giwa Halima Bukola
    To link to this article: https://doi.org/10.21315/mjps2025.23.2.5 ABSTRACT Hypertension (HTN) is a leading cause of disability and death in both developing and developed countries with lifestyle/dietary modification playing a strong role in both prehypertension and hypertensive state. The research was carried out among 317 patients at University of Ilorin Teaching Hospital, Nigeria, who were randomised into control (158) and intervention (159) groups. Intervention was carried out after baseline study and 6 months with evaluation at 6 months and 12 months. A self-developed standardised questionnaire, with a Cronbach’s alpha of 0.849, was used to assess patients’ knowledge, while quality of life was evaluated using the World Health Organization Quality-of-Life Scale (WHOQOLBREF) standardised questionnaire. A total of 136 participants in the control group and 139 in the intervention group completed the study. The mean age of the patients was 59.2 ± 12.5 with male = 141 (44.5%) while female = 176 (55.5%). Baseline characteristics were comparable. Following intervention, 6 months and 12 months knowledge difference was significant (p < 0.001). A significantly different practice in physical activity (p < 0.001) was observed at 6 months while all the four area of practice were significantly different at 12 months. The practice of dietary modification in the intervention group was similarly significantly different in the intervention group at 6 months and 12 months (p < 0.05). Significant reduction in alcohol intake (p < 0.001), dietary sodium (p < 0.001) and increase in physical activity were associated with improved quality of life but, not reduction in sugar intake (p = 0.325). Good practice of lifestyle and dietary modification was found to improve quality of life among hypertensive patient.
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    Phytochemical Analysis and Antioxidant Activity of Partition Fractions of Hibiscus sabdariffa and Vernonia amygdalina
    (Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Ilorin, 2024-12) Njinga Ngaitad Stanislaus; Egharevba Godshelp Osas; David Susan Mosebolatan; Mbakop Carline; Abdulazeez Iyabode Fatima; Olorukooba Halima Omolara; Olayiwola Olabisi Oreoluwa; Salawu Muritala Kayode; Shittu Abiodun Olatunji
    The calyx of Hibiscus sabdariffa and the leaf of Vernonia amygdalina are plant parts which are widely consumed in Nigeria. These plant parts are known for their numerous medicinal uses which is a function of the phytochemicals present in them. This study was undertaken to investigate and compare the phytochemical constituents and antioxidant activities of the petroleum ether, chloroform, ethyl acetate, acetone and methanol fractions of the calyx of H. sabdariffa and the leaf of V. amygdalina to ascertain their medicinal values. Phytochemical studies were done using standard methods such as Fehling’s test, alkaline reagent test, Keller-Kiliani test and spectrophotometric techniques. The antioxidant activities were carried out through DPPH (1,1-diphenyl-2- picrylhydrazyl) radical scavenging effects. The preliminary phytochemical analysis of the extracts of Hibiscus sabdariffa and Vernonia amygdalina revealed the presence of varying amounts of alkaloids, saponins, tannins, terpenoids, cardiac glycosides, phenols and flavonoids. The petroleum ether, chloroform, ethyl acetate and methanol fractions of Vernonia amygdalina contained alkaloids while only the chloroform fraction of Hibiscus sabdariffa contained alkaloids. The difference in alkaloidal content of the chloroform fractions of both plant extracts was not statistically significant at P<0.05. The methanol fraction of both plants contained saponins with Vernonia amygdalina showing a higher percent of saponin compared to that of Hibiscus sabdarriffa although the difference was not statistically significant at P<0.05. Vernonia amygdalina contained more flavonoids in all fractions than Hibiscus sabdariffa. The difference in concentration of flavonoids between the fractions of both plant was statically significant at P<0.05. The phenolic content of the petroleum ether, chloroform and methanol fractions of H. sabdariffa were higher than that of V. amygdalina but the difference was not statistically significant at P<0.005 while the phenolic content of the ethyl acetate and acetone fractions of Vernonia amygdalina were statistically higher than that of Hibiscus sabdariffa. Amongst all the fractions, the methanolic fraction of Hibiscus sabdariffa showed the highest antioxidant activity of 90.57 % at a concentration of 0.25 mg/ml. The activity decreased with an increase in the concentration.The result of the phytochemistry and antioxidant activity of the calyx of Hibiscus sabdariffa and the leaf of Vernonia amygdalina ascertained; the medicinal values of these plants, the folkloric claims and their wide consumption.