Browsing by Author "Abdulazeez, A"

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    Case report of challenges in the management of a rare ductal dependent complex congenital heart disease in a Nigerian tertiary hospital
    (College of Health Sciences, Osun State University, Osun, Nigeria, 2016) Abdulkadir, Mohammed Baba; Olaosebikan, R; Abdulazeez, A; Owolabi, B
    Objective: Complex congenital heart defects are rare and may be difficult to define. They often require early surgery for palliation or correction. A lack of facilities and manpower to provide surgery in developing countries often results in mortality. Case report:A6 month old male infant referred to our unit on account of failure to thrive, cyanosis since birth, easy fatigability and breathlessness. On examination he was small for age with tachycardia and a grade III pansystolic murmur at the left lower sternal edge. Chest radiograph revealed an “egg on side” cardiac appearance with cardiomegaly. Echocardiography confirmed the presence of d-transposition of the great arteries with a patent foramen ovale, large ventricular septal defect and atresia of the proximal main pulmonary artery. The child died while being prepared for referral to a centre for palliative surgery. Conclusion: Transposition of the great arteries with pulmonary atresia is an uncommon congenital heart disease. Early intervention with palliative surgery is necessary to prevent mortality.
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    Challenges in the management of mucopolysaccharidosis Type II (Hunter’s Syndrome) in a developing country: a case report.
    (College of Health Sciences, Jimma University, Ethiopia, 2015-07) Ibraheem, Rasheedat; Oladele, Patrick; Abdulazeez, A; Abdulkadir, M; Katibi, S; Ibraheem, G
    BACKGROUND: Mucopolysaccharidosis type II (Hunter's syndrome) is an X-linked chromosomal storage disorder due to deficiency of the lysosomal enzyme iduronate-2-sulfatase with patients rarely living till adulthood. Failure to identify patients early could contribute to an increased morbidity as identified in this case report. CASE DETAILS: An eight year old patient with Hunter's syndrome identified five years after disease onset with severe cardiovascular complications exemplifies the challenges faced in resource-limited countries towards making diagnosis and treatment of rare conditions. Elevated urinary glycosaminoglycans levels or a strong clinical suspicion of Hunter's syndrome, as identified in the index case, is a prerequisite for enzyme activity testing. Urinary mucopolysaccharide(MPS) level was 69.6 mg/mmol(normal range is 0.0 - 11.6 mg/mmol), and the confirming MPS electrophoresis analysis showed elevated heparan sulphate in the urine sample. Enzyme activity testing, with absent or very low iduronate-2-sulfatase activity, is diagnostic. However, the scarce availability and high cost of these tests is another constraint in making a diagnosis. CONCLUSION: Identification and management of mucopolysaccharidosis type II pose a problem in resource-constrained countries due to late presentation, lack of facility for diagnosis and treatment, cost and expertise required for the management.