Browsing by Author "ABDUL-OLUMOH, HIDAYAH AYODEJI"

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    EVALUATION OF DIURETIC ACTIVITY OF METHANOL LEAF EXTRACT OF CLERODENDRUM VOLUBILE IN SALINE-TREATED RATS
    (Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria, 2022) AIYELERO, OYERONKE MEDINAT; OJUADE, FATIMOH IDOWU; ABDUL-OLUMOH, HIDAYAH AYODEJI; IBEGBUNAM, CHISOM OLIVIA; AYANNIYI, RASHIDAT OLUWAFUNKE
    Clerodendrum volubile is used for the local management of fluid retention or edema. This present study aimed to evaluate the diuretic activity of the methanol leaf extract of Clerodendrum volubile, (MCV) family - Labiatae on experimental animals at 200-800 mg/kg body weight respectively. The animals were observed for different indicators of diuresis such as volume, electrolyte concentration, and pH of urine for 5 hours using standard methods. Methanol leaf extract of Clerodendrum volubile (MCV) induced diuresis and produced a non-significant increase (p<0.05) in urine output when compared to the negative control group. The 200 mg/kg dose of MCV produced the highest volume. In addition, the extract produced non-significant increase in the saliuretic and natriuretic activity when compared with furosemide 10 mg/kg. MCV may still be considered to have favorable natriuretic effects since the computed values were above 2.0 which is the benchmark for natriuretic effects. From this study, it can be inferred that MCV may have diuretic activity thus justifying its ethnomedicinal use in the management of fluid over load.
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    Evaluation of Nutraceutical content and topical Anti-inflammatory Activities of Turraea vogelii Hook F. Ex Benth (Meliaceae)
    (Arak University of Medical Sciences, 2019-02) ABDUL-OLUMOH, HIDAYAH AYODEJI; AYANNIYI, Rashidat Oluwafunke; OJUADE, FATIMOH IDOWU; AGBANA, REMILEKUN JUSTINA
    Background: Turraea vogelii has been used as traditional medicine for the treatment of ailments including wounds, stomach aches, malaria, infections, filariasis cutaneous, among others and, it serves as source of food. The present study aimed to evaluate the nutraceuticals content and topical anti-inflammatory effect of hydro-methanol twig extract of Turraea vogelii (METV). Method: METV was obtained using cold maceration with water and methanol in ratio 30:70. The concentration of vitamins A, C and E, total phenolic and total flavonoid contents were evaluated by UV spectrophotometric method. Phenol and xylene-induced ear edema was used to evaluate the topical anti-inflammatory effect in mice. Results: The concentration of vitamins A, C and E was found to be 0.113 0.006, 9.303 0.012 and 0.020 0.001 mg in 100g of dried plant materials, respectively. Total phenolic and flavonoid contents were 0.281 0.318 mg/g gallic acid equivalent and 0.112 mg/g quercetin equivalent, respectively. Topical application of METV at a dose of 25 and 50mg/ear in xylene-induced ear edema produced significant inhibition (P<0.05) of 33 and 54% while in phenol-induced ear edema was significantly (P< 0.05) reduced by 44% and 34%. Dexamethasone (0.1mg/ear) produced an inhibition of 83% and 57% in phenol-induced ear edema. Conclusion: Results from this study demonstrated that Turraea vogelii twigs contain flavonoids and phenolic compounds, which may be responsible for the topical anti-inflammatory effect of the plant extract.