Browsing by Author "A. Nyamngee"

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    Evidences of Endemic Schistosoma haematobium Infection among School Children in Shonga Community, Edu Local Government Area, Kwara State, Nigeria.
    (The Tropical Journal of Health Sciences, 2018-01) A. Nyamngee; K. A. Yusuf; L.D. Edungbola; A.A. Akanbi II; A A. Njaan; S. K. Olubiyi
    A study was carried to determine the presence, level of endemicity and the intensity of human Schistosoma haematobium infection in Shonga community of Edu Local Government Area in Kwara State, Nigeria. For permission and maximum cooperation, intensive advocacy and mobilization of the community leaders, school authorities and the pupils preceded the collection of urine specimens which were preserved in 10% alcohol. Microscopic examinations were carried out on the urine specimens. Conclusive diagnosis was based on the characteristic terminal spined egg of S. haematobium. Altogether, 1,479 pupils (60.0% boys and 40.0% girls), aged between 4-20 years, were examined in the over sixteen schools in and around the community, selected by convenience. Of all the pupils examined, 1,144 (77.4%) had the characteristic eggs of S. haematobium in their urine samples. Infection rate for boys was 516 (45.1%) while it was 296 (25.9%) for girls. Thus, boys were significantly more infected than girls (P<0.05). Children between 11-13 years of age had the highest prevalence of infection (47.2%) while those between 4-7 years of age had the least prevalence (30.0%). The overall mean egg-count for the 1,144 infected pupils was 1,598.0±49.32, while the mean egg-counts for boys and girls were 1,213.0±25.6 and 685.0±18.3 respectively. The difference in the intensity of infection between boys and girls was also significant (p<0.05). Of the 1,144 pupils who were infected with S. haematobium 195 (17.0%) had egg-count range of 1-1000, 758 (66.3%) had egg-count range of 1001-5000 while 191 (16.7%) had egg-count range of ≥5001. The prevalence of haematuria was also significantly higher among boys than girls (p<0.05). This study reveals that human Schistosoma haematobium infection is endemic in Shonga community. The awareness about the impact, transmission and prevention of this infection was relatively poor. Research on vaccine development to support the existing chemotherapy for the control and possible elimination of this dreaded but highly neglected parasitic infection should be the priority. Therefore, advocacy, health education chemotherapy and vaccine most be adopted concurrently as the best intervention strategy/approach to eradicate Schistosomiasis.
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    Genetic Diversity of Plasmodium falciparum Based on Merozoite Surface Proteins 1 and 2 Genes
    (Genetic diversity of Plasmodium falciparum, 2022-05) A. Nyamngee; Edogun H.A.; Sulaiman M.K.; Ikpe R.T.; Njan A.A.
    Genetic diversity of Plasmodium falciparum is an important feature that makes the parasite a successful pathogen and is a risk factor for generating mutant variants involved in pathogenicity, drug resistance and immune evasion. A study was designed to determine the diversity of P. falciparum isolates based on merozoite surface protein 1 and 2, determine the predominant circulating allelic families and multiplicity of infection in Nigeria. The diagnosis was based on finding the characteristic asexual stage of the parasite in Giemsa-stained blood smears under a compound microscope. The Deoxyribonucleic acid was extracted from P. falciparum positive blood using Chelex extraction method followed by PCR-genotyping, targeting the merozoite surface proteins. Nested polymerase chain reaction and restriction fragment length polymorphisms were used to detect Plasmodium falciparum chloroquine resistance transport, P. falciparum multidrug resistance 1, P. falciparum dihydrofolate reductase and P. falciparum dihydropteroate synthase. Data were analysed using the Statistical Packages for Social Sciences Version 21.0 at a significance level of P<0.05. Overall, multiplicity of infection with MSP 1 and MSP 2 markers was 1.32 and 1.24 respectively. P. falciparum isolates demonstrated diverse nature in respect of MSP 1 (block 2) and MSP 2 (block 3). All the families of MSP 1 and MSP2 were detected. It was concluded that the genetic diversity of P. falciparum was comparatively high. Therefore, strategies that reduce multiple-strain infections should be implemented in order to improve antimalarial drug efficacy and reduce the rate of spread of drug resistance.
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    Haematological parameters of normal pregnant women during antenatal clinic booking in ilorin, North Central Nigeria
    (J.Appli Basic Science, 2017-06) Babatunde AS; Olawumi HO; Durotoye IA; Shittu AO; Adesina KT; Sani MA; A. Nyamngee
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    KNOWLEDGE, ATTITUDE AND PREVENTIVE PRACTICE AGAINST LASSA FEVER AMONG UNDERGRADUATE OF ACHIEVERS UNIVERSITY OWO, ONDO STATE.
    (Global Journal of Health Related Researches, 2020-03-12) S. K. Olubiyi; A. Nyamngee; U. IkehIfunanya; V.M Olubiyi; A.R Ayeni; A. Samuel
    Lassa fever is a dangerous disease that affects human. It is caused by Lassa fever virus which is found mostly in multi-mamate rats (rat that have many breasts. Lassa fever is an animal-borne or zoonotic acute viral illness and member of Arenaviridae. This study assessed the knowledge, attitude and preventive practices against Lassa fever among students of Achievers University, Owo, Ondo State, Nigeria. The research design was descriptive survey, using a structured questionnaire which was administered to 330 respondents. Findings showed that 315 (99.5%) of respondents reported high level of knowledge, 281 (85.1%) respondents had positive attitude towards preventing Lassa fever. Majority 277 (83.9%) of respondents employed a good practice method against Lassa fever. Based on the findings, policy makers at all level should provide administrative support for providing the necessary equipment and logistics for care. The general public should continually be sensitized on the need on precautionary measures to take against Lassa fever, health workers should engage in sustained and improved health information for the general public on the causes, course, symptoms and prevention of Lassa fever.