Browsing by Author "....... Gwadabe Sadiya Musa................. et al"

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    Timing of surgery following SARS-CoV-2 infection: An international prospective cohort stud
    (Association of Anaesthestetics Great Britain and Ireland., 2021-02-26) Nepogodiev, D.; Simoes, J. Ff; Li, E.,; Bhangu, A..............; ....... Gwadabe Sadiya Musa................. et al
    Summary Peri-operative SARS-CoV-2 infection increases postoperative mortality. The aim of this study was to determine the optimal duration of planned delay before surgery in patients who have had SARS-CoV-2 infection. This international, multicentre, prospective cohort study included patients undergoing elective or emergency surgery during October 2020. Surgical patients with pre-operative SARS-CoV-2 infection were compared with those without previous SARS-CoV-2 infection. The primary outcome measure was 30-day postoperative mortality. Logistic regression models were used to calculate adjusted 30-day mortality rates stratified by time from diagnosis of SARS-CoV-2 infection to surgery. Among 140,231 patients (116 countries), 3127 patients (2.2%) had a pre-operative SARS-CoV-2 diagnosis. Adjusted 30-day mortality in patients without SARS-CoV-2 infection was 1.5% (95%CI 1.4–1.5). In patients with a pre-operative SARS-CoV-2 diagnosis, mortality was increased in patients having surgery within 0–2 weeks, 3–4 weeks and 5–6 weeks of the diagnosis (odds ratio (95%CI) 4.1 (3.3–4.8), 3.9 (2.6–5.1) and 3.6 (2.0–5.2), respectively). Surgery performed ≥ 7 weeks after SARS CoV-2diagnosiswasassociatedwithasimilarmortalityrisk tobaseline(oddsratio(95%CI)1.5(0.9–2.1)). After a ≥ 7 weekdelayinundertakingsurgery following SARS-CoV-2 infection, patients with ongoing symptoms hada highermortalitythanpatientswhosesymptomshadresolvedorwhohadbeenasymptomatic(6.0%(95%CI3.2 8.7) vs. 2.4%(95%CI1.4–3.4)vs.1.3%(95%CI0.6–2.0),respectively).Wherepossible,surgeryshouldbedelayed for at least 7 weeksfollowingSARS-CoV-2infection.Patientswithongoingsymptoms≥ 7 weeksfromdiagnosis maybenefitfromfurtherdelay