Phytochemical and antioxidant screening of the fruit and seed extract of Phoenix dactylifera linn and evaluation of its toxicological profile in albino rats

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dc.contributor.authorAbdul-Olumoh, H.A.
dc.contributor.authorAyanniyi, R.O.
dc.contributor.authorNjinga, N.S
dc.contributor.authorOjuade, F.I.
dc.contributor.authorAiyelero, O.M.
dc.contributor.authorKuranga, R.A.
dc.date.accessioned2023-05-17T10:24:48Z
dc.date.available2023-05-17T10:24:48Z
dc.date.issued2023
dc.description.abstractBackground: Phoenix dactylifera (date palm) is a common plant with various known benefits. The plant's health benefits have been associated with its high antioxidant profile. Objectives: To conduct phytochemical, antioxidant, metal and vitamin analysis, and evaluate the hematological and biochemical effects of the fruit and seed extracts of Phoenix dactylifera. Methods: Evaluation of Phoenix dactylifera for phytochemicals was conducted using standard methods. Quantitative determination of total phenolics, total flavonoids, and various in vitro antioxidant activities (DPPH FRAP) was carried out using colorimetric methods. Results: Phytochemical analysis shows the presence of alkaloids, flavonoids, terpenoids, phenols and tannins in both extract. The antioxidant activity was also found to be 83.86 to 88.43% for seeds and 63.49 to 85.06% for fruit. The fruit and seed extracts contained Vit A (0.52/0.46 IU/100g), C (16.26/0.79 mg/100g), and (45.63/49.87 mg/100g). Metal analysis indicated the presence of Mg, Zn, Ca, Cu, I and K with the seeds having higher concentration of the metals than the fruits. Serum biochemical analysis indicated no deleterious effects on vital organs, no significant changes observed in the levels of ALT, AST, albumin, bilirubin and total protein. The histopathological findings in the kidney and of rats treated with the extract were found to be normal Hematological parameters showed no significant difference from control but MPV and MCV concentration were decreased significantly (p<0.05) in animals treated with 100 mg/kg of the methanol seed extract. The body weights increased in a dose-dependent manner in rats treated with fruits extract. Conversely, a decrease in body weight was observed in those treated with seed extract. Conclusion: The seed and fruit extract of Phoenix dactylifera did not produce any toxic effect in the rats.en_US
dc.identifier.issn2384-6674
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/10355
dc.language.isoenen_US
dc.publisherThe West African Postgraduate College of Pharmacist.en_US
dc.subjectAntioxidants, Phoenix dactylifera, fruits, seed extracten_US
dc.titlePhytochemical and antioxidant screening of the fruit and seed extract of Phoenix dactylifera linn and evaluation of its toxicological profile in albino ratsen_US
dc.typeArticleen_US

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