Anacardium occidentale and Psidium guajava effectively reduce ethanol-induced gastric ulcer in male Wistar rats

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dc.contributor.authorOyabambi, A. O.
dc.contributor.authorOyeniyi, P. O.
dc.contributor.authorOjulari, L. S.
dc.contributor.authorOladoye, O. D.
dc.date.accessioned2025-05-05T13:31:57Z
dc.date.available2025-05-05T13:31:57Z
dc.date.issued2016
dc.description.abstractUlcer is one of the world’s major gastrointestinal disorders affecting a good percentage of the populace in industrialised and developing countries. Plant extracts are some of the most attractive sources of new drugs and have shown promising results for the treatment of gastric ulcer as they possess a variety of natural therapeutic products. This study aimed to look at the effect of combining Anacardium occidentale and Psidium guajava on the management of gastric ulcer. The extracts of the leaves of Anacardium occidentale and Psidium guajava were tested in ethanol-induced ulcer models in rats. Oral administration of these plant extracts and reference drug was done for two weeks for 30 male Wistar rats divided into five (5) groups. The treatment with the combination of the extracts stock solutions at a dose of 150 mg/kg each exhibited a significant (p < 0.05) decrease in gastric volume, 2.1×10⁷ mEq/L, and ulceration, 2.0±0.26 than the individual extract groups when compared to control 4.0×10⁷ mEq/L and 5.2±0.60 respectively, while cimetidine at the dose tested had the highest percentage reduction. The efficacy of the extracts presented here confirms that the combination of Anacardium occidentale and Psidium guajava possess better synergistic ulcer healing and gastric protective effects than the individual components. This affirms their efficacy in the management of ulcers.
dc.identifier.citationOyabambi, A. O., Oyeniyi, P. O., Ojulari, L. S., & Oladoye, O. D. (2016). Anacardium occidentale and Psidium guajava effectively reduce ethanol-induced gastric ulcer in male Wistar rats. Centrepoint Journal (Science Edition), 22 (2), 78-91, Published by University of Ilorin, Ilorin, Nigeria
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16053
dc.language.isoen
dc.publisherPublished by University of Ilorin, Ilorin, Nigeria
dc.relation.ispartofseries22 (2); 78-91
dc.subjectGastric ulcer
dc.subjectAnacardium occidentale
dc.subjectPsidium guajava
dc.subjectCimetidine
dc.subjectEthanol
dc.subjectGastric acid Secretion
dc.subjectMale Wistar rats
dc.titleAnacardium occidentale and Psidium guajava effectively reduce ethanol-induced gastric ulcer in male Wistar rats
dc.typeArticle

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