Pharmaco-epidemiologic Survey and Experimental Study of Co-Administration of Three Herbal Products with Paracetamol

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dc.contributor.authorBamidele, OD; Adegbolagun, OM; Subair, HG; Emikpe, BO
dc.date.accessioned2021-10-26T10:49:25Z
dc.date.available2021-10-26T10:49:25Z
dc.date.issued2018-06-01
dc.description.abstractPharmacoepidemiological survey of the use of herbal products and orthodox drugs was carried out within a university community using structured questionnaires. Three commonly used herbal products; Oroki Herbal Mixture® (OH), Mama Decoction® (MD) and Alomo Bitters® (AB) and co-administration with paracetamol were investigated based on the dosage instructions. Analgesic activity was evaluated using Hotplate method to determine the pain reaction time (PRT), while haematological and biochemical analysis and histopathological evaluation of the organs were carried out at the end of the study using standard procedures. All the herbal products showed significant analgesic activity, co-administration with paracetamol resulted in slight reduction in the PRT of AB and OH, while MD showed a significant reduction in time to reach peak PRT from 120 minutes to 30minutes. There was no significant effect on PCV, RBC and Hb level, while varied effect on other haematological parameters was observed by the co-administration with paracetamol. Co-administration of AB and MD increased alanine aminotransferase (ALT), while reduction was observed in OH. All the herbal products and their combination with paracetamol showed various stages of liver damage. Marked testicular degeneration was observed with co-administration of the herbal products with paracetamol, while kidney morphology was normal in all the treatments. All the herbal products investigated showed analgesic activities with synergistic enhancement of analgesic activity of paracetamol by Mama Decoction. However, their effect and their coadministration with paracetamol on some of the biochemical and haematological parameters as well as the damage to the liver and testes call for caution.en_US
dc.identifier.citationBamidele, O. D., Adegbolagun, O. M., Subair, H. G & Emikpe, B.O. (2018): Pharmaco-epidemiologic Survey and Experimental Study of Co-Administration of Three Herbal Products with Paracetamol. African Journal of Biomedical Research 21(2): 153-159.en_US
dc.identifier.issn1119-5096
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/6740
dc.language.isoenen_US
dc.publisherBiomedical communications Group, Ibadan, Nigeriaen_US
dc.subjectParacetamolen_US
dc.subjectAnalgesic activityen_US
dc.subjectHerbal productsen_US
dc.subjectHaematological parametersen_US
dc.subjectBiochemical parametersen_US
dc.titlePharmaco-epidemiologic Survey and Experimental Study of Co-Administration of Three Herbal Products with Paracetamolen_US
dc.typeArticleen_US
dc.typePreprinten_US

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