ANTI FUNGAL EFFECT OF TOPICALLY ADMINISTERED NEEM (Azadirachta indica) SEED OIL CREAM AGAINST PYTIRIASIS VERSICOLOUR
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Date
2008
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DEPARTMENT OF PHARMACEUTICS AND PHARMACEUTICAL TECHNOLOGY, FACULTY OF PHARMACY, OLABISI ONABANJO UNIVERSITY, SHAGAMU
Abstract
The study was carried out to evaluate the antifungal effect of Neem seed oil cream against
Pytiriasjs verstcolour infection of the skin. Fifteen samples of 20 g each i.e. three samples
each of concentrations, 2.5% w/w, 5.0% w/w,7.50/o w/w/ andIO.00/o w/w neem seed oil
cream and a commercial preparation (Whitfield Ointment) were given out to patients
randomly. Double blind approach was adopted in prescribing the samples to the patients
diagnosed to have Pityriasis vesicolour fungal infection of the skin; double blind in the
sense that both clinician and patients were blinded as to the identity of the samples. The
clinical responses to neem seed oil cream concentrations 2.5% w/w and 5.0 w/w were not
encouraging. However, at concentrations 7.5% w/w and 10.0% w/w , neem seed oil cream
showed excellent improvement in clinical conditions of the patients infected with Pityriasis
versicolour on their skins. They compared favourably with the commercial control sample.
Keywords: neem seed oil, Pytrriasis versicolour, cream, topical
Description
Keywords
neem seed oil, Pytrriasis versicolour, cream, topical