Anti-anaemia Potential and Safety of Morinda lucida Leaf Extracts in Balb/c Mice Induced with Rhabdomyosarcoma Cells

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dc.contributor.authorAla, A.A
dc.contributor.authorAbdulkareem, A.O
dc.contributor.authorAkomolafe, D.F
dc.contributor.authorOhia, C.M.D
dc.date.accessioned2023-04-03T07:30:01Z
dc.date.available2023-04-03T07:30:01Z
dc.date.issued2017-11
dc.description.abstractAnaemia, a major health challenge, results from factors including dietary deficiencies and malaria. Although reports from previous studies show that Morinda lucida is effective in the treatment of anaemia resulting from these conditions, little information exist to suggest its beneficial effects in treating anaemia resulting from cancer. This study therefore examined the anti-anaemia potential of M. lucida leaf extracts in Balb/c mice inoculated with rhabdomyosarcoma (RD) cells. Forty mice inoculated intra-peritoneally with RD cells were randomly divided into eight groups: A (untreated); Treatment groups —B1, B2 and B3 (100, 200 and 300 mg/kg aqueous M. lucida extracts respectively); C1, C2 and C3 (100, 200 and 300 mg/kg M. lucida ethanolic extractsrespectively) and D (Cisplatin).Themice were treated for 2 weeks and thereafter, blood samples were collected through the orbital sinus for haematological and serum biochemical analyses. ComparedwithgroupA(3.25±0.03), ethanolic leaf extractsofM.lucida 3 increasedwhite blood cell count(x10 ul)significantly (p?0.05)in groups C1,C2, andC3 (5.45±0.03, 6.00±0.05, and 5.60±0.10 respectively) but there was no significantincrease of the packed cell volume in groups C andE.Comparedwith groupA, aspartate aminotransferase (AST)levels were significantly lower in all treatment groups, and alkalinephosphatase levels(ALP)significantly lower in group B. The treatments therefore did not improve all haematological parameters in RD cell-bearing mice but elicited increased immune responses, were safe at the doses administered andconsequentlymaybebeneficialincancer therapy.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/8965
dc.subjectAnaemiaen_US
dc.subjectCanceren_US
dc.subjectSafetyen_US
dc.subjectMorinda lucidaen_US
dc.subjectHaematological parametersen_US
dc.titleAnti-anaemia Potential and Safety of Morinda lucida Leaf Extracts in Balb/c Mice Induced with Rhabdomyosarcoma Cellsen_US
dc.typeArticleen_US

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