Development and Characterization of Ibuprofen Solid Dispersion for Solubility and Dissolution improvement using a binary carrier system consisting of D- Mannitol - Polyethylene Glycol 6000
dc.contributor.author | Shittu, A.O. | |
dc.contributor.author | Njinga, N.S. | |
dc.contributor.author | Orshio, S.D. | |
dc.date.accessioned | 2024-05-13T09:43:40Z | |
dc.date.available | 2024-05-13T09:43:40Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: Adequate drug bioavailability is a major problem in most solid dosage formulations. Recent works reported enhanced solubility and dissolution using a carrier. This study was carried out to enhance the solubility and dissolution of ibuprofen using a binary carrier system. Method: Solid dispersions (SD) of ibuprofen were prepared using PEG 6000 and D (-) mannitol in different ratios (1:0:4, 1:1:3, 1:2:2, 1:3:1, and 1:4:0) by the fusion method. Results: Percentage yield of SD was between 96% and 99% and content analysis revealed 100 % drug content. All batches of SD showed better solubility characteristics than Ibuprofen alone or its physical mixtures. The SD batch 3, ratio 1:2:2 with equal amount of PEG and mannitol possessed the best solubility characteristic and drug release profile with T at 17 min. FTIR spectral and DSC thermograms of SDs showed no 50% interaction between the carriers and ciprofloxacin. Conclusion: The SD3 formulated with 20 % ibuprofen, 40 % mannitol and 40 % PEG 6000 possessed. | |
dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/123456789/14138 | |
dc.language.iso | en | |
dc.publisher | Pharmaceutical Society of Nigeria | |
dc.relation.ispartofseries | 55; 1 | |
dc.title | Development and Characterization of Ibuprofen Solid Dispersion for Solubility and Dissolution improvement using a binary carrier system consisting of D- Mannitol - Polyethylene Glycol 6000 | |
dc.type | Article |
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