Leaf extract of Morinda lucida improves pancreatic beta-cell function in alloxan-induced diabetic rats

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dc.contributor.authorAbdulkareem, A.O.
dc.contributor.authorIgunnu, Adedoyin
dc.contributor.authorAlad, A.A.
dc.contributor.authorOlatunji, L.A.
dc.date.accessioned2020-05-22T22:34:40Z
dc.date.available2020-05-22T22:34:40Z
dc.date.issued2019-09
dc.description.abstractChemotherapy remains the utmost treatment for Type 1 diabetes (T1D) patients. This however, predisposes the patients to a wide range of serious complications, thus, the need for alternative therapeutic agents that target pancreatic β-cell function. This study investigated the effects of aqueous leaf extract of M. lucida (MLE) on β-cell dysfunction and atherogenic dyslipidaemia in alloxan-induced T1D in rats. Twenty-five Wister rats (156- 168g) were randomly divided into normal, diabetic, diabetic + glibenclamide (5 mg/kg), diabetic + 120 mg/kg MLE and diabetic + 240 mg/kg MLE groups (n = 5/ group). Treatments were via oral route for 14 days. Our findings revealed that, 120 mg/kg MLE significantly reduced hyperglycaemia, improved insulinaemia as well as β-cell function, and attenuated weight loss in alloxan-induced diabetic rats. The extract also attenuated (p<0.05) atherogenic dyslipidaemia and malondialdehyde. The activities of the extract compared favourably with glibenclamide. This study suggested that, hypoglycaemic and mitigating effects of aqueous leaf extract of M. lucida on atherogenic dyslipidaemia and pancreatic β-cell dysfunction were through reduction in lipid peroxidation. The extract may therefore represent an effective source of novel drugs against TID and cardiovascular diseases. Further study is recommended, to explore the extract’s mechanism of oxidative repair.en_US
dc.description.sponsorshipFunded by the authorsen_US
dc.identifier.urihttps://doi.org/10.1080/2314808X.2019.1666501
dc.identifier.urihttp://hdl.handle.net/123456789/3959
dc.language.isoenen_US
dc.publisherPublished by Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.relation.ispartofseriesEGYPTIAN JOURNAL OF BASIC AND APPLIED SCIENCES;
dc.subjectType 1 diabetesen_US
dc.subjectβ-cell functionen_US
dc.subjectlipid peroxidationen_US
dc.subjectweight lossen_US
dc.subjectMorinda lucidaen_US
dc.subjectextracten_US
dc.titleLeaf extract of Morinda lucida improves pancreatic beta-cell function in alloxan-induced diabetic ratsen_US
dc.typeArticleen_US

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