Aristolochia repens stem bark ameliorates liver and kidney function in high-fat diet and streptozotocin-induced diabetic rats.
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Date
2023-12-29
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A journal published by Nigerian Society for Experimental Biology.
Abstract
Aristolochia repens, is among such herb utilized locally for managing diabetes and related problems.
The study evaluated the ameliorative effects of aqueous extract of Aristolochia repens stem bark on liver
and kidney function in high-fat diet and streptozotocin-induced diabetic rats. Type 2 diabetes was
induced in rats with high-fat diet and low dose of streptozotocin (35 mg/kg body weight). Non-diabetic
male Wistar rats were treated with distilled water (Naïve control) while the diabetic male Wistar rats
were treated with distilled water, Metformin (100 mg/kg body weight), 50, 100 and 200 mgkg-1 body
weight of aqueous extract of Aristolochia repens stem bark for 28 days. The rats were sacrificed and sera
were collected and analyzed. High-fat diet and streptozotocin significantly altered (P<0.05) the alanine
aminotransferase, aspartate aminotransferase activities, concentration of total bilirubin, total protein,
albumin, globulin, creatinine, urea, potassium, sodium, bicaronate and chloride when compared with
Naïve and positive control. Wistar rats treated with 50, 100 and 200 mgkg-1 body weight of aqueous
extract of Aristolochia repens significantly did not altered (p>0.05) the alanine aminotransferase and
aspartate aminotransferase activities, when compared with Naive and Metformin group. Similarly, the
concentration of total bilirubin, total protein, albumin, globulin, creatinine, urea, potassium, sodium,
bicaronate and chloride was not significantly altered (p>0.05) when compared with the Naïve and
Metformin group. This study suggests that Aristolochia repens stem ameliorates liver and kidney
function in high-fat diet and streptozotocin-induced diabetic rats and hence may be safe for use in the
management of diabetes.