Effects of selected aqueous plant extracts on heamatological parameters of Plasmodium berghei infected mice.

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dc.contributor.authorAbubakar, F.A.
dc.contributor.authorAdetutu, A.
dc.contributor.authorOlorunnisola, O.S
dc.contributor.authorSoji-Omoniwa, O
dc.contributor.authorAbdulazeez, A.T
dc.contributor.authorAborisade, A.B
dc.date.accessioned2023-06-30T10:05:53Z
dc.date.available2023-06-30T10:05:53Z
dc.date.issued2016
dc.description.abstractCymbopogon citrates leaves, Khaya senagalesis stem bark, Parquetina nigrescens leaves, Psidium guajava leaves, Terminalia glaucescens stem bark and Zingiber officinale rhizome are used traditionally to treat malaria. This study evaluate the effects of the aqueous extracts of C. citrates leaves, K. senagalesis stem bark, P. nigrescens leaves, P.guajava, T. glaucescens stem bark and Z. officinale rhizome respectively on the heamatological status of NK 65 Plasmodium berghei (chloroquine sensitive parasite) infected mice. Fourty five (45) albino mice with average weight 25.5 ± 1.45g were randomly grouped into nine (9). Mice in group A serve as control not infected. Groups B, C, D, E, F, G, H and I were inoculated intraperitoneally with P. berghei. Groups C, D, E, F, G, H and I were treated with 5 mg/kg body weight of chloroquine, 200mg/kg body weight of C. citrates, K. senagalesis, P. nigrescens, P. guajava, T. glaucescens and Z. officinale aqueous extracts respectively. On day 5, red blood cell count (RBC), white blood cell count (WBC), packed cell volume, haemoglobin count (Hb), lymphocyte and neutrophil counts were assessed. There were significant (p<0.05) increase in the Hb count, RBC and PCV levels of the extract treated P. berghei infected mice in each group when compared with the untreated P. berghei infected mice. In the extracts treated infected mice, lymphocyte count was significantly (p<0.05) increased with concomitant decrease in neutrophil count. Our Findings show that all the extracts used has anti-anaemic properties and anti-inflammatory potential with extracts of P. nigrescens, P. guajava, T. glaucescens and Z. officinale demonstrating higher potential.en_US
dc.identifier.issn0794-0378
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/11385
dc.language.isoen_USen_US
dc.publisherFaculty of Physical Sciences and Faculty of Life Sciences, University of Ilorin, Nigeria.en_US
dc.subjectCymbopogon citratesen_US
dc.subjectKhaya senagalesisen_US
dc.subjectParquetina nigrescens,en_US
dc.subjectPsidium guajava,en_US
dc.subjectTerminalia glaucescensen_US
dc.subjectZingiber officinaleen_US
dc.subjectPlasmodium bergheien_US
dc.subjectanti-anaemic propertiesen_US
dc.titleEffects of selected aqueous plant extracts on heamatological parameters of Plasmodium berghei infected mice.en_US
dc.typeArticleen_US

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