Evaluation of the Safety and Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for Treating Childhood Malaria in Ilorin, Nigeria

Simple item page
dc.contributor.authorAgede, Olalekan Ayodele
dc.contributor.authorMokuolu, Olugbenga
dc.contributor.authorFalade, Olufunke
dc.date.accessioned2023-07-13T13:03:11Z
dc.date.available2023-07-13T13:03:11Z
dc.date.issued2021-10-30
dc.description.abstractArtemether-lumefantrine (AL), the ACT of first choice for the treatment of malaria in Nigeria though efficacious and well tolerated has a 6-dose regimen over three days and requires co-administration with a fatty meal for optimal absorption and efficacy. This may lead to poor compliance and consequent loss of efficacy over time. Dihydroartemisinin-piperaquine (DP) is another ACT with high efficacy and good tolerability available in Nigeria with a more user-friendly dosing regimen. In an open label randomized clinical trial, we compared the safety and efficacy of artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP) among 110 children aged 6 – 120 months with symptomatic acute uncomplicated malaria in Ilorin north-central Nigeria. Enrolees were followed up for 28days.107 of 110 (97.3%) enrolees completed the study. The mean age of enrolees was 71.95 ±33.25 months (range 7-120) and 47.2% (51/110) were males. Geometric mean parasite density among children who received AL was 19,158/μL (range 1,200 -197,333) and 21,908/μL (range 1024 - 186,182) for those treated with DP (ρ=0.718). Parasite clearance time for AL treated children was significantly shorter than among those treated with DP (2.35 ± 0.71 days versus 2.71±0.61 days) respectively (ρ=0.001). Fever clearance time was also significantly shorter among children who received AL (1.86 ± 0.61 versus 2.17 ± 0.43 respectively (ρ=0.005). Crude D28 cure rate was 100% among both treatment groups. AL and DP were well tolerated. AL and DP were safe and efficacious in the treatment of acute uncomplicated malaria in children from north-central Nigeria.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/11492
dc.language.isoenen_US
dc.publisherFaculty of Basic Medical Sciences, University of Ibadanen_US
dc.subjectArtemether-lumefantrine, Dihydroartemisinin-piperaquine, malaria, Nigeriaen_US
dc.titleEvaluation of the Safety and Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for Treating Childhood Malaria in Ilorin, Nigeriaen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
3. Evaluation of the Safety and Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for Treating Childhood Malaria in Ilorin, Nigeria.pdf
Size:
400.9 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections