Analgesic and Anti-Inflammatory Activities Of Ethanolic Extract Of The Stem Bark Of Kigelia Africana In Wistar Albino Mice and Rats

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Date

2012-03

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Nigerian Journal of Pharmaceutical Sciences

Abstract

Kigelia africana (Lam) Benth has various ethno-medicinal uses in different parts of Africa. In the present study, defatted ethanolic extract of the stem bark of Kigelia africana was evaluated for analgesic effects in rats using an analgesy-meter and in mice using the tail immersion and acetic acid-induced writhing tests. The anti-inflammatory property of the extract was assessed in rats using the carrageenan-induced paw edema model. Graded doses (25, 50 and 100 mg/kg) of Kigelia africana extract were administered intra-peritoneally 30 minutes prior to the induction of mechanical, thermal or chemically-induced pain in the rats and mice. Kigelia africana exhibited a dose-related and significant anti-nociceptive effect against acetic acid induced abdominal constrictions in mice. At a dose of 50 mg/kg the percentage of pain inhibition was 49.20% (p<0.01) while at 100 mg/kg, there was a 71.12% inhibition (p<0.01). The results of the tail immersion test in mice and from the analgesy- meter test in rats, also demonstrated that Kigelia africana exhibited significant analgesic properties. In addition, the extract produced significant antiinflammatory effect in the rats. These results confirm and justify the traditional use of Kigelia africana stem bark for its analgesic and anti-inflammatory properties. They also suggest that the analgesic activity of the extract is mediated via inhibition of central and peripheral mechanisms. Inhibition of carrageenan-induced inflammation by the extract may be mediated in part by a non-selective cyclooxygenase inhibitory mechanism.

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Kigelia africana, Analgesic, Anti-inflammatory, Rats, Mice, Carrageenan

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