EVALUATION OF DIURETIC ACTIVITY OF METHANOL LEAF EXTRACT OF CLERODENDRUM VOLUBILE IN SALINE-TREATED RATS

Simple item page
dc.contributor.authorAIYELERO, OYERONKE MEDINAT
dc.contributor.authorOJUADE, FATIMOH IDOWU
dc.contributor.authorABDUL-OLUMOH, HIDAYAH AYODEJI
dc.contributor.authorIBEGBUNAM, CHISOM OLIVIA
dc.contributor.authorAYANNIYI, RASHIDAT OLUWAFUNKE
dc.date.accessioned2023-04-26T11:20:56Z
dc.date.available2023-04-26T11:20:56Z
dc.date.issued2022
dc.description.abstractClerodendrum volubile is used for the local management of fluid retention or edema. This present study aimed to evaluate the diuretic activity of the methanol leaf extract of Clerodendrum volubile, (MCV) family - Labiatae on experimental animals at 200-800 mg/kg body weight respectively. The animals were observed for different indicators of diuresis such as volume, electrolyte concentration, and pH of urine for 5 hours using standard methods. Methanol leaf extract of Clerodendrum volubile (MCV) induced diuresis and produced a non-significant increase (p<0.05) in urine output when compared to the negative control group. The 200 mg/kg dose of MCV produced the highest volume. In addition, the extract produced non-significant increase in the saliuretic and natriuretic activity when compared with furosemide 10 mg/kg. MCV may still be considered to have favorable natriuretic effects since the computed values were above 2.0 which is the benchmark for natriuretic effects. From this study, it can be inferred that MCV may have diuretic activity thus justifying its ethnomedicinal use in the management of fluid over load.en_US
dc.identifier.issn0794-800X
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/9299
dc.language.isoenen_US
dc.publisherFaculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeriaen_US
dc.subjectClerodendrum volubile; Leaf; Diuretic; Saliuretic; Ratsen_US
dc.titleEVALUATION OF DIURETIC ACTIVITY OF METHANOL LEAF EXTRACT OF CLERODENDRUM VOLUBILE IN SALINE-TREATED RATSen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
EVALUATION OF DIURETIC ACTIVITY OF METHANOL LEAF EXTRACT OF CLERODENDRUM VOLUBILE IN SALINE-TREATED RATS.pdf
Size:
365.69 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections