Effect of Aqueous Extract of Ocimum gratissimum (Scent Leaf) on Renal Profile of Male Wistar Rats

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dc.contributor.authorAkeem Olayinka Busari
dc.contributor.authorFatimoh Abimbola Salau
dc.contributor.authorShefiat Bashir
dc.contributor.authorMoshood Bolaji
dc.contributor.authorMorufu Eyitayo Balogun
dc.contributor.authorMunirdeen Ibrahim
dc.contributor.authorMunirdeen Ibrahim
dc.contributor.authorWasiu Olanrewaju Garuba
dc.contributor.authorNiyi Abdulgafar Popoola
dc.contributor.authorGodwin O. Adunmo
dc.date.accessioned2025-05-03T15:58:09Z
dc.date.available2025-05-03T15:58:09Z
dc.date.issued2021-12
dc.description.abstractHumans have given the leaves of Ocimum gratissimum (O. gratissimum) a great deal of attention due to their vast medical usefulness, culinary application, and pharmacological effects. As a result, the study evaluated the effect of O. gratissimum on renal profile of male Wistar rats. Ten healthy male Wistar rats were randomized into test and control groups comprising of 5 animals each. The test group received 400mg/Kg O. gratissimum leaf extract whereas the control group was fed with normal rat diet and water. The rats were euthanized through cervical dislocation at the end of the experiment and blood sample was collected through heart puncture for serum assessment renal profile while the kidney was excised for histological examination. The Results showed a non-significant at p>0.05 increase in serum electrolytes and urea while significant at p<0.05 decrease in the mean serum creatinine level was observed in the test group compared to the control group. Also, the histological examination of the kidney tissue revealed a mild lymphocytic infiltration in the test group compared to the control group. Conclusively, the study suggested a dose-dependent toxicological effect of O. gratissimum on renal profile.
dc.identifier.citationOcimum gratissimum Electrolytes Urea Creatinine
dc.identifier.issnP-ISSN: 2811-1516 E-ISSN: 2811-1524
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/15954
dc.language.isoen
dc.publisherAl-Hikmah Journal of Health Sciences (AJOHS)
dc.relation.ispartofseriesVol.1, No.1, ; 7-13
dc.titleEffect of Aqueous Extract of Ocimum gratissimum (Scent Leaf) on Renal Profile of Male Wistar Rats
dc.typeArticle

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