Preinduction oral clonidine: Effects on ketamine cardiostimulation at induction of anaesthesia.

Simple item page
dc.contributor.authorSuleiman, Zakari Aliyu
dc.contributor.authorKolawole, Israel Kayode
dc.contributor.authorBolaji, Benjamin olusomi
dc.date.accessioned2018-05-31T14:21:57Z
dc.date.available2018-05-31T14:21:57Z
dc.date.issued2016
dc.description.abstractMost of the available intravenous (IV) induction agents produce hypotension except ketamine. However, its use is limited due to cardiovascular stimulation. We therefore investigated the effects of oral clonidine premedication on ketamine-induced cardiostimulation. This was a prospective, double-blind randomized controlled study of 156 patients scheduled for general anaesthesia. The patients were randomized into three Groups A, B and C of 52 patients each and all the patients received 10mg diazepam the night before the surgery and 90 minutes before induction of anaesthesia. In addition, patients in Groups A and B received 0.1 mg and 0.3 mg oral clonidine, respectively, at the time of premedication while no clonidine was administered in Group C. Anaesthesia was induced with IV ketamine 2mg/kg and 100% oxygen 8 L/min via the Bain circuit. The pulse rate (PR), systolic blood pressure, diastolic blood pressure, and mean arterial pressure were measured noninvasively and recorded every 10 min before induction of anaesthesia. RESULTS: The peak values of PR in the 0.1 mg and 0.3 mg clonidine groups were significantly lower than the corresponding value in the control (C) group (86 ± 5 bpm and 83 ± 7 bpm vs. 118 ± 14 bpm, p < 0.05). however, the peak mean blood pressure in Group B was significantly reduced when compared with the corresponding values in the Groups A and C (97 ± 9 mm Hg vs 117 ± 7 mm Hg and 115 ± 14 mm Hg, respectively p < 0.05. Preanaesthetic oral clonidine reduced cardiostimulation following ketamine-induction in spontaneously breathing patients.en_US
dc.description.sponsorshipUITH Support for Residents' Dissertationen_US
dc.identifier.citationSuleiman ZA, Kolawole IK, Bolaji B.O. (2016). Preinduction oral clonidine: Effects on ketamine cardiostimulation at induction of anaesthesia. Journal of Medicine in the Tropics, 18(1): 12-17.en_US
dc.identifier.issn2276-7096
dc.identifier.urihttp://hdl.handle.net/123456789/310
dc.language.isoenen_US
dc.publisherCollege of Medical Sciences, University of Jos, Josen_US
dc.subjectAttenuation,en_US
dc.subjectcardiovascular stimulations,en_US
dc.subjectketamine-induction,en_US
dc.subjectpre-anaesthetic clonidine,en_US
dc.subjectspontaneous breathing.en_US
dc.titlePreinduction oral clonidine: Effects on ketamine cardiostimulation at induction of anaesthesia.en_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
BOLAJI JOMT CLONIDINE 1.pdf
Size:
392.38 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.69 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections