Testicular microanatomical and hormonal alterations following use of antiretroviral therapy in Sprague Dawley rats: Role of Naringenin

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dc.contributor.authorAdana, M. Y.
dc.contributor.authorAkang, E. N.
dc.contributor.authorNaidu, E. C. S.
dc.contributor.authorAniekan, P. I.
dc.contributor.authorKouame, K.
dc.contributor.authorOffor, U.
dc.contributor.authorAzu, O. O.
dc.date.accessioned2025-05-16T15:33:29Z
dc.date.available2025-05-16T15:33:29Z
dc.date.issued2018
dc.description.abstractHuman immunodeficiency virus‐infected man may require assisted reproductive technology not just for safer conception but also due to subfertility. The study investigated the effect of antiretroviral drugs on the fertility potentials of males and the possible protective role of Naringenin, using Sprague Dawley rats. Thirty adult male Sprague Dawley rats were grouped into—A: Distilled water; B: Highly Active Antiretroviral Therapy (HAART); C: Naringenin 40 mg/kg; D: Naringenin 80 mg/kg, E: HAART + Naringenin 40 mg/kg; F: HAART + Naringenin 80 mg/kg. The rats were euthanised after 10 weeks. Results showed a significant decrease in sperm count in group B when compared to the control and other groups. Spermatozoa with normal morphology also reduced significantly in the B group and progressive sperm motility reduced when compared to the control, D and the F group. The serum testosterone was not significantly different between groups A and B, however the groups C and D displayed significant increase when compared to groups A and B. The serum luteinis‐ing hormone was significantly higher in group B when compared to groups A, E and F. Our data suggest that Naringenin improves the male reproductive anatomy and function, therefore, it promises to be a beneficial adjuvant for mitigating HAART testicular and reproductive perturbations.
dc.identifier.citation(2018). Testicular microanatomical and hormonal alterations following use of antiretroviral therapy in Sprague Dawley rats: Role of Naringenin. Andrologia, 50(9), e13137. Published by Wiley- Blackwell. Available online at https://onlinelibrary.wiley.com/toc/14390272/2018/50/9 Scopus link: https://onlinelibrary.wiley.com/doi/abs/10.1111/and.13137 (Scopus indexed, Q2)
dc.identifier.issn1439-0272
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16752
dc.language.isoen
dc.publisherWiley- Blackwell
dc.subjectantiretroviral therapy
dc.subjecthormones
dc.subjectmale infertility
dc.subjectsemen parameters
dc.subjectSprague Dawley
dc.subjecttestis
dc.titleTesticular microanatomical and hormonal alterations following use of antiretroviral therapy in Sprague Dawley rats: Role of Naringenin
dc.typeArticle

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