Nigella sativa Attenuates Trimethyltin-induced Histopathological Changes in Mice Hippocampi

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dc.contributor.authorAdana M.Y.
dc.contributor.authorImam, A.
dc.contributor.authorKareem, S. B.
dc.contributor.authorAjao, M. S.
dc.date.accessioned2025-05-09T15:12:27Z
dc.date.available2025-05-09T15:12:27Z
dc.date.issued2022
dc.description.abstractBackground: The organotins particularly Trimethyltin (TMT) are very popular in agriculture and industry. Exposure to the compound is associated with several neurological symptoms which suggest neurotoxicity. The study was designed to investigate the antidotal effects of Nigella sativa (NS) on TMT-induced neurotoxicity on mice hippocampi. Materials and Methods: Seventy adult male mice weighing an average of 25g were randomly assigned into seven groups of ten animals each (Groups A- G). Animals in group A were administered single dose TMT (3mg/kg) and euthanized after 48 hours. Groups B, C, and D were given a single dose of TMT (3mg/kg), followed by a single weekly dose of NS (28ml/kg) for 1, 2, and 3 weeks respectively. Groups E, F, and G served as controls for trimethyltin (3mg/kg), Nigella sativa (28ml/kg), and saline (28ml/kg) respectively. NS Results: The mice demonstrated tremors, aggressiveness and subtle seizures at the initial state in TMT administered groups with exophthalmos and pedal edema that subsides in the mice administered with TMT-NS. There were exudes of neuritic plaques, neurofibrillary tangles, and apoptotic cells on TMT-administered brains on histology. These observations were markedly reduced in the TMT-NS administered groups. Conclusion: The study concludes that the neurodestructive effects of TMT on the hippocampal neurons and its ability to negatively affect the neurobehavioral attitudes of the mice could be reversible following the administration of NS
dc.identifier.citationAdana, M. Y., Imam, A., Kareem, S. B. & Ajao, M. S. (2022). Nigella sativa Attenuates Trimethyltin-induced Histopathological Changes in Mice Hippocampi. Nigerian Journal of Basic and Applied Medical Sciences, 1(1), 57-62. Published by the National Association of Specialist Medical Doctors in Academics in Nigeria. Available online at https://njbams.asmeda.org.ng/view_volume.php?volume=2&issue=1&year=2022
dc.identifier.issn2811-1680
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16577
dc.language.isoen
dc.publisherNational Association of Specialist Medical Doctors in Academics in Nigeria
dc.subjectNigella ssativa
dc.subjectTrimethyltin
dc.subjectHippocampus
dc.subjectNeurotoxicity
dc.titleNigella sativa Attenuates Trimethyltin-induced Histopathological Changes in Mice Hippocampi
dc.typeArticle

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