Evaluation of multifunctional activity of bioactive peptide fractions from the leaves of Nauclea diderrichii (De Wild. and T. Durand) Merrill and Ixora brachypoda DC
| dc.contributor.author | Omonike, O. Ogbole | |
| dc.contributor.author | Abraham, Nkumah | |
| dc.contributor.author | Toluwanimi, E. Akinleye | |
| dc.contributor.author | Fredrick, E. Olisaedu | |
| dc.contributor.author | Alfred, F. Attah | |
| dc.date.accessioned | 2021-12-10T09:11:51Z | |
| dc.date.available | 2021-12-10T09:11:51Z | |
| dc.date.issued | 2021-02 | |
| dc.description.abstract | Bioactive peptides are known for health-promoting properties due to several pharmacological effects they modulate in physiological systems. Herein, the presence of peptides particularly cyclic peptides, was investigated in two Rubiaceae members; Nauclea diderichii (De Wild. and T. Durand) Merrill and Ixora brachypoda DC by thin layer chromatography (TLC) chemical detection, and their multifunctional bioactivity evaluated. Crude and pre-purified peptides were obtained from both plants using aqueous and solid-phase extractions, respectively. The peptide fraction of N. diderrichii showed good DPPH scavenging activity (IC50 = 3.43 μg/mL) compared to the standard Gallic acid (IC50 = 1.44 μg/mL). Peptide fractions of both plants displayed inhibitory effects (MIC = 6.25 μg/mL) against bacteria and fungi strains except Escherichia coli, relative to standard drugs (MIC = 0.31 μg/mL). Both displayed significant toxicity to brine shrimp nauplii (LC50≤ 220.8 μgmL-1) as well as MCF-7 and RD cancer cells (IC50 ≤ 34.0 μgmL-1). The enterovirus species B and C tested were remarkably susceptible to the peptide fractions (IC50 ≤ 3.20 μg/mL). | en_US |
| dc.identifier.citation | Omonike O. Ogbole , Abraham Nkumah , Toluwanimi E. Akinleye , Fredrick E. Olisaedu , Alfred F. Attah , Evaluation of multifunctional activity of bioactive peptide fractions from the leaves of Nauclea diderrichii (De Wild. and T. Durand) Merrill and Ixora brachypoda DC, Phytomedicine Plus (2021), doi: https://doi.org/10.1016/j.phyplu.2021.100019 | en_US |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/20.500.12484/7123 | |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier B.V. | en_US |
| dc.relation.ispartofseries | Vol. 1;Num. 1 | |
| dc.subject | Cyclic peptides | en_US |
| dc.subject | Rubiaceae | en_US |
| dc.subject | Antimicrobial | en_US |
| dc.subject | Antiviral | en_US |
| dc.subject | Antioxidant | en_US |
| dc.subject | Cytotoxicity | en_US |
| dc.title | Evaluation of multifunctional activity of bioactive peptide fractions from the leaves of Nauclea diderrichii (De Wild. and T. Durand) Merrill and Ixora brachypoda DC | en_US |
| dc.type | Article | en_US |