EFFECT OF HEPATITIS-B VIRUS CO-INFECTION ON CD4 CELL COUNT AND LIVER FUNCTION OF HIV INFECTED PATIENTS

Simple item page
dc.contributor.authorH.O. OLAWUMI
dc.contributor.authorD.O. OLANREWAJU
dc.contributor.authorA.O. SHITTU
dc.contributor.authorI.A. DUROTOYE
dc.contributor.authorA.A. AKANDE
dc.contributor.authorA. NYAMNGEE
dc.date.accessioned2025-05-09T10:52:36Z
dc.date.available2025-05-09T10:52:36Z
dc.date.issued2014-06
dc.description.abstractBackground: Human immunodeficiency virus (HIV) and Hepatitis B virus (HBV) share similar routes of transmission, making it possible for an individual to have a co-infection. HBV infection is well known to be a major cause of chronic liver diseases worldwide. The aim of this study was to determine the prevalence of HBV infection among HIV infected HAART naïve patients and investigate the effect of co-infection on CD4 count and liver function. Study design: This was a hospital based descriptive cross sectional study of one hundred consecutive thera- py-naive HIV-infected individuals. The CD4 count, Hepatitis B surface antigen, Serum albumin, total Pro- tein, and liver enzymes were determined using standard techniques. Results: The prevalence of HIV and HBV co-infection was 37%. The mean serum ALT and ALP were signifi- cantly higher in the co- infected patients (P-values <0.05). The mean CD4 count of the mono infected patients was significantly higher (p-value of 0.014). The mean serum ALT, AST and ALP of mono and co- infected patients with CD4 count<200/μl were signifi- cantly higher than those with count ≥ 200 cells/μl. (p- value of <0.01). The mean ALT and AST of the co - infected patients and all patients with CD4 count <200 cells/μl were higher than the normal reference range. Conclusion: Approximately one third of HIV positive patients had hepatitis B virus co-infection. Co- infection and CD4 count <200 cells/μl are likely to result in abnormal ALT and AST. We recommend those co-infected patients and those with CD4 count <200 cells/μl should be given non-hepatotoxic an- tiretroviral drug.
dc.identifier.citationHIV, Hepatitis B, CD4 count, liver func- tion, co-infection
dc.identifier.issn0016-9560
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/16542
dc.language.isoen
dc.publisherGHANA MEDICAL JOURNAL
dc.relation.ispartofseriesVolume 48, Number 2; 96-100
dc.titleEFFECT OF HEPATITIS-B VIRUS CO-INFECTION ON CD4 CELL COUNT AND LIVER FUNCTION OF HIV INFECTED PATIENTS
dc.typeArticle

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ajol-file-journals_267_articles_106950_submission_proof_106950-3181-291156-1-10-20140825.pdf
Size:
203.95 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections