Nephroprotective Effects of Anona Muricata Leaf Extract on Adenine-Induced Renal Failure in Male Wistar Rats.
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Date
2021
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Volume Title
Publisher
Society for Conservation of Phytofuels and Sciences.
Abstract
Renal failure is a prevalent disease in Africa, partly as a result of indiscriminate consumption
of various medical herb preparations such as Annona muricata, which is locally used for
several ailments like inflammation, bacterial and parasitic infections, diabetes, liver diseases
amongst others. The present study was aimed at investigating the effect of Annona muricata
leaf (AML) extract on adenine-induced renal failure in male Wistar rats. Thirty-five rats were
divided into five groups, with seven rats per group. Each of the rats in groups II-V were given
50mg/kg adenine for induction of renal failure for a period of 14 days. The rats in groups III V were treated with 50mg/kg, 100mg/kg and 200mg/kg of the extract respectively following
induction of renal failure, while group II was left untreated for a period of 28 days totaling 42
days all together. Rats in group I served as Control. Urinalysis was done prior to the end of
the experiment. The animals were euthanised and blood samples collected for assessment of
haematocrit, plasma electrolytes, urea and creatinine. Significant sodium reduction was
observed in co-administration of 50mg AML and 50mg adenine, and 50mg adenine alone.
Significantly increased potassium was noticed in co-administration 50mg AML and 50mg
adenine, and 50mg adenine alone. Significant increase was noted in both urea and creatinine
levels of co-administration of 50mg or 100mg AML and 50mg adenine. Haematocrit was only significantly increased in the 200mg AML administration group. There was global
proteinuria in all AML intervention groups which was seemingly dose dependent.AML, if
administered at a high dose has a nephron-protective effect against acute renal failure perhaps
due to modulation in some ion channels in renal tubules.
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Citation
Annona muricata, renal failure, nephro-protection, adenine.