Extractive Values and Diuretic Activity of Methanol Extract of Three Varieties of Hibiscus sabdariffa Linn (Malvaceae) in Wistar Albino Rats

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dc.contributor.authorUsman, Sukurat
dc.contributor.authorAyanniyi, Rashidat
dc.contributor.authorAbdullah, AbdulRasheed
dc.contributor.authorMusa, Mariam
dc.contributor.authorLawal, Bilqis
dc.contributor.authorSalawu, Kayode
dc.contributor.authorAttah, Alfred
dc.date.accessioned2019-10-17T11:05:42Z
dc.date.available2019-10-17T11:05:42Z
dc.date.issued2018-12
dc.description.abstractHibiscus sabdariffa Linn (Malvaceae) is widely cultivated in Nigeria as food and for medicinal purposes. The calyx is the most frequently used part of the plant and has been reported to have antioxidant, antihypertensive and diuretic activity. The aim of the present study is to determine the extractive values and diuretic activity of three varieties of H. sabdariffa. Aqueous, methanol, ethanol, chloroform and hexane soluble extractive values were determined. The effect of the extracts of H. sabdariffa on urine output was evaluated and the concentration of sodium and potassium in blood was also determined. The results showed that water extract had the highest extractive value (32.90%, 26.50% and 29.00%) for the three varieties (Dark red, Light red and Green) respectively. H. sabdariffa extract (100 mg/kg G) produced a significant (p<0.05) increase in urine output compared to the control. The diuretic activity of extract was comparable with the standard drug Hydrochlorothiazide (10 mg/kg). The other species of H. sabdariffa extract produced no significant increase in urine output. H. sabdariffa extract (200 mg/kg G) showed a significant (p<0.05) natriuretic activity compared to control. There was no significance difference in the serum potassium levels for all the three varieties at the doses employed. The study showed that water is the most suitable solvent for extraction of the calyx of H. sabdariffa and the green variety produced a significant increase in urine output with potassium sparing activity.en_US
dc.identifier.issn2579-0455
dc.identifier.urihttp://hdl.handle.net/123456789/2672
dc.language.isoenen_US
dc.publisherFaculty of Pharmaceutical Sciences, University of Ilorin.en_US
dc.subjectHibiscus sabdariffaen_US
dc.subjectCalyxen_US
dc.subjectExtractive Valuesen_US
dc.subjectDiuretic Activityen_US
dc.subjectHydrochlorothiazideen_US
dc.titleExtractive Values and Diuretic Activity of Methanol Extract of Three Varieties of Hibiscus sabdariffa Linn (Malvaceae) in Wistar Albino Ratsen_US
dc.typeArticleen_US

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