STIGMASTEROL ISOLATION AND ANTICONVULSANT ACTIVITY OF METHANOL EXTRACT FROM THE AERIAL PARTS OF INDIGOFERA STENOPHYLLA (FABACEAE)

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dc.contributor.authorA.Sanusi
dc.contributor.authorH.S. Hassan
dc.contributor.authorS. Sani
dc.contributor.authorL. A. Akinpelu
dc.contributor.authorH. Muhammad
dc.contributor.authorY. M. Ado
dc.contributor.authorR B. Tomilayo
dc.contributor.authorA.J. Yusuf
dc.contributor.authorA. Muntaka
dc.contributor.authorF.A. Echu
dc.contributor.authorS. Muhammad
dc.contributor.authorN.S. Njinga
dc.contributor.authorS.T Abdullahi
dc.contributor.authorR. O. Ayanniyi
dc.contributor.authorM.T. Bakare-Odunola
dc.date.accessioned2026-09-04T10:31:28Z
dc.date.available2026-09-04T10:31:28Z
dc.date.issued2026
dc.description.abstractIndigofera stenophylla, a member of the Fabaceae family, has been traditionally used in folk medicine for various ailments, including epilepsy among others. This study aimed to isolate and characterize phytochemical(s) from the methanol aerial parts extract of Indigofera stenophylla (MAEIS) and evaluate its anticonvulsant potential. Methods: The MAEIS affords the isolation of compound AR2 through chromatography. The anticonvulsant effect of MAEIS was determined using pentylenetetrazol (PTZ) and strychnine (SCN) induced seizure models. Results: The spectroscopic analysis of the compound AR2 affords 3β, 22.-stigmasta-5, 22-dien-3-ol (stigmasterol). The MAEIS demonstrated significant anticonvulsant activity at graded doses of 150, 300, and 600 mg/kg, reducing both seizure onset and duration in PTZ and SCN models at p<0.05 and p<0.001. The 600 mg/kg dosage provided the most substantial protection. Conclusion: The column chromatographic and spectroscopic analysis of MAEIS led to the isolation of stigmasterol which is a potential bioactive compound with anticonvulsant activity. This is the first isolation of stigmasterol from the plant.
dc.identifier.citation(61) Abdulrazaq Sanusi, H. S. Hassan, S. Sani, L. A. Akinpelu, H. Muhammad, Y. M. Ado, R.B. Tomilayo, A.J. Yusuf, A. Muntaka, F.A. Echu, S. Muhammad, N.S. Njinga, S.T Abdullahi, R.O. Ayanniyi, M.T. Odunola-Bakare. (2025): Stigmasterol Isolation and Anticonvulsant Activity of Methanol Extract from the Aerial Parts of Indigofera Stenophylla (FABACEAE), Bulletin of Pharmaceutical Sciences Assiut University, 48(2), 1065-1077
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/123456789/18524
dc.language.isoen
dc.publisherBulletin of Pharmaceutical Sciences Assiut University
dc.titleSTIGMASTEROL ISOLATION AND ANTICONVULSANT ACTIVITY OF METHANOL EXTRACT FROM THE AERIAL PARTS OF INDIGOFERA STENOPHYLLA (FABACEAE)
dc.typeArticle

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