Anti-retroviral therapy and the risk of sexual transmission of HIV: a systematic review and meta-analysis

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dc.contributor.authorMajid D., Giwa H. B., Nabizade A., Taheri F.,Giwa A
dc.date.accessioned2023-05-11T10:47:52Z
dc.date.available2023-05-11T10:47:52Z
dc.date.issued2020
dc.description.abstractObjectives The aim of this study was to evaluate the effect of antiretroviral therapy (ART) with or without condom use on the risk of sexual transmission of HIV. Methods A search of the literature was conducted in the PubMed, Web of Science, Cochrane, SCOPUS and EMBASE databases for studies dating back to 2008. The results were summarized as relative risks and incidence rates with 95% confidence intervals (CIs). The effect sizes were pooled using random-effects models and heterogeneity was evaluated using the Cochrane Q test and I2. Results Of the 1424 studies retrieved in the initial search, 10 met the eligibility requirements. ART was associated with a 52% reduction in transmission risk compared to no ART, with a relative risk of 0.48 (95% CI 0.439–0.525) (Q = 0.524; I2 = 0.0%; overall effect Z = 15.99, P < 0.0001). ART vs. no ART caused a reduction in the risk from 5.6 person-years (95% CI 3.26–9.62 person-years) (Q = 0.771; I2 = 0.0%; overall effect Z = 6.25, P < 0.0001) in the untreated group to 0.85 person-years (95% CI 0.28– 2.99 person-years) (Q = 0.038; I2 = 76.7%; overall effect Z = 0.11, P = 0.772) in the treated group, but not significantly so, which is equivalent to an 84% reduction in the risk of sexual transmission. In accordance with the Swiss National AIDS Commission declaration, ART with suppressed viral loads was associated with a minimal risk of transmission, with a median time at risk of 0.00 person-years (95% CI 0.00–0.00 person-years) (Q = 1.00; I2 = 0.0%; overall effect Z = 6.80, P < 0.0001). Conclusions ART and condom use were found to cause a significant reduction in the risk of sexual transmission of HIV in both homosexual and heterosexual populations, based on previous systematic reviews and meta-analyses.en_US
dc.identifier.citationMajid D., Giwa H. B., Nabizade A., Taheri F.,Giwa A. (2020): Anti-retroviral therapy and the risk of sexual transmission of HIV: a systematic review and meta-analysis. HIV Medicine, 21 (6); 349-357, Published by British HIV Association. Available online at https://onlinelibrary.wiley.com/doi/epdf/10.1111/hiv.12841en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/hiv.12841
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/10081
dc.language.isoenen_US
dc.publisherBritish HIV Associationen_US
dc.subjectantiretroviral therapy, HIV, infection, infectivity, serodiscordant, transmissionen_US
dc.titleAnti-retroviral therapy and the risk of sexual transmission of HIV: a systematic review and meta-analysisen_US
dc.typeArticleen_US

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