Impact of groundwater samples and leachates from Gbagede dumpsite, Amoyo, Kwara State, Nigeria, on testes and prostate of male Wistar rats: A biochemical and histological study.
| dc.contributor.author | Yakubu, M.T. and Omar, S.A. | |
| dc.date.accessioned | 2024-05-02T14:42:41Z | |
| dc.date.available | 2024-05-02T14:42:41Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | This study evaluated the impact of groundwater samples and leachate from Gbagede dumpsite in Amoyo, Kwara State, on the testicular and prostatic function indices of male rats. The groundwater sample 1 (GW1), groundwater sample 2 (GW2), 2.5%, 5.0%, 7.5% and 10.0% leachate progressively reduced (p < .05) feed intake, groundwater and leachate intake, body weight, weights of testes and prostate, and testes–body weight ratio. The groundwater and leachates significantly (p < .05) reduced the sperm count, motility, normal morphology and testicular volume; activities of semen acid phosphatase (ACP) and α-glucosidase, testicular alkaline phosphatase, ACP, ᵧ-GT, lactate dehydrogenase, glutathione reductase, catalase and superoxide dis mutase; testicular total protein, glycogen, total cholesterol, sialic acid, testosterone, reduced glutathione, total antioxidant capacity, zinc, iron and copper; serum LH and FSH; prostatic calcium and phosphate. Treatments increased testicular malondialdehyde, prostate-specific antigen and ACP whilst prostatic pH remained significantly unaltered. Only the leachates reduced prostate–body weight ratio. The treatments induced distortions of seminiferous tubules, destroyed spermatogonic cells and degenerated prostatic acinus. The study concluded that metals in the groundwater and leachate samples have adversely impacted on the testes and prostates of the male rats via endocrine disruption and oxidative stress, with attendant implications on reproductive capacity. | |
| dc.identifier.uri | https://uilspace.unilorin.edu.ng/handle/123456789/13251 | |
| dc.publisher | Wiley-Blackwell Publishing Ltd | |
| dc.title | Impact of groundwater samples and leachates from Gbagede dumpsite, Amoyo, Kwara State, Nigeria, on testes and prostate of male Wistar rats: A biochemical and histological study. |