The Protective Effect of Croton zambesicus against Carbon Tetrachloride-induced Renal Toxicity in Rats

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dc.contributor.authorAyanniyi, R.O
dc.contributor.authorOlumoh-Abdul, H.A
dc.contributor.authorOjuade, F.I
dc.contributor.authorAbdullahi, R.A
dc.date.accessioned2021-06-01T10:56:18Z
dc.date.available2021-06-01T10:56:18Z
dc.date.issued2019-02
dc.description.abstractBackground: The leaf extract of Croton zambesicus (CZ) is used in traditional medicine for the management of various conditions including kidney disease. The purpose of this study was to determine the protective effects of leaf extract of CZ on rat kidney toxicity induced by carbon tetrachloride. Method: Male albino rats were divided into 6 groups of 5 rats and treated for 5 days with aqueous extract (200-400 mg/kg) and n-butanol fraction (20-40 mg/kg) of CZ. Carbon tetrachloride (2 ml/kg of 40% in olive oil) was administered subcutaneously for 3 days and the rats were treated with the extract and fraction for 3 days. Animals were euthanized on day 8 with intraperitoneal injection of ketamine (60 mg/kg) and xylazine (7.5 mg/kg). Blood sample was collected for the analysis of serum electrolytes, urea and creatinine. Kidney tissue was harvested to determine the antioxidant enzyme activity. Results: Carbon tetrachloride produced increased serum sodium ion, chloride ion, urea and creatinine with decreased superoxide, catalase, glutathione, oxidized glutathione and an increase in malondialdehyde concentration. Treatment of rats with the aqueous leaf extract and n-butanol fraction attenuated the toxic effects of carbon tetrachloride on kidney with a significant decline in serum electrolytes, urea, creatinine and a significant increase in the concentration of antioxidant enzymes. Conclusion: Results from this study revealed that the aqueous leaf extract and n-butanol fraction of CZ had protective effect against carbon tetrachloride-induced renal toxicity in rats, thus justifying the consideration of this plant for the management of kidney disease.en_US
dc.description.sponsorshipSenate Research Granten_US
dc.identifier.citationAyanniyi RO, Olumoh-Abdul HA, Ojuade FI, Abdullahi R, Anafi SB (2019). The Protective Effect of Croton zambesicus against Carbon Tetrachloride-induced Renal Toxicity in Rats. Iranian Journal of Toxicology. 15;13(1):5-8.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5642
dc.language.isoenen_US
dc.publisherIranian Journal of Toxicologyen_US
dc.relation.ispartofseries15;13(1);5-8
dc.subjectAntioxidant Enzymesen_US
dc.subjectCarbon Tetrachlorideen_US
dc.subjectCroton Zambesicusen_US
dc.subjectNephroprotective Activityen_US
dc.subjectSerum Electrolytesen_US
dc.titleThe Protective Effect of Croton zambesicus against Carbon Tetrachloride-induced Renal Toxicity in Ratsen_US
dc.typeArticleen_US

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